2017_SBRT_Course Book

Proton re-irradiation

Multi-Institutional Prospective Study of Reirradiation with Protons: Ø Median interval 19 months; median CTV 108cc Ø Conventionally fractionated 66Gy, 2/3 concomitant CT

11.5% grade V toxicity

Median OS 15 months

Ø Overall, results appear similar to Photon re-irradiation Chao JTO 2017

07.09.17 ESTRO SBRT 2017 - Matthias Guckenberger

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Proton re-irradiation

Factors influencing toxicity At the initiation of the study, patients were stratified as either low volume (CTV <250 cm3) or high volume ( CTV >250 cm3 ). The high-volume patients in the full thoracic cohort of the proton reirradiation protocol were subsequently deemed infeasible because of inability to complete the prescribed treatment course owing to toxicity .

Ø Limitation of overall volume and central overlap volume Chao JTO 2017

07.09.17 ESTRO SBRT 2017 - Matthias Guckenberger

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