2017_SBRT_Course Book

What dose is now actually required? n=505 n=395

1.0

0.9

0.8

0.7

0.6

0.5

0.4

Local control

0.3

0.2

0.1

0.0

0

20

40

60

80 100 120 140 160 180 200

BED 10

Perscription dose PTV (Gy)

Grills JTO 2010; Ohiri IJROBP 2012

Guckenberger Radiother Oncol 2013

= 3 x 18Gy

Ø Very limited gain in TCP for doses >100Gy BED

Matthias Guckenberger - ESTRO SBRT Course 2017

07.09.17

17

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Late recurrences in stage I NSCLC

Japanese prospective study: N=180

Swedish phase II trial: N=57

Shibamoto JTO 2015

Lindberg Acta Oncol 2015

Median FU 52.5 months 4 x 11-13 Gy @ isocenter

Median FU 41.5 months 3 x 15Gy @ 67%

• Very few recurrences after 3 – 5 years Ø Validity of TCP modelling

Matthias Guckenberger - ESTRO SBRT Course 2017

07.09.17

18

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