AOAC SPADA VNGS - Final

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Forward and backward compatibility shall be ensured. Absence of critical information data that is

backward compatible shall be noted. Critical information and metadata shall not be omitted for forward 144

compatibility. The addition of new data items for future updates shall be enabled. Encoding and 145

decoding algorithms shall be referenced, e.g., ISO 23092 (19, 20, 21, 22, 23, 24, 25). 146

147

( e ) Data types

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Numerical values shall be denoted as measured, inferred, or assumed data in SI units. Measured

data shall include information on the method of obtaining data (if applicable) and measurement 150

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precision, uncertainty, and accuracy.

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Nucleic acid sequence data shall be encoded according to the recommendations of the International

Union of Pure and Applied Chemistry (IUPAC) and the International Union of Biochemistry and 153

Molecular Biology (IUBMB) in the “Biochemical Nomenclature and Related Documents” (known as the 154

White Book), released by the IUPAC-IUBMB Joint Commission on Biochemical Nomenclature and 155

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Nomenclature Commission of IUBMB.

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( f ) Format validation

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The sequence provider should enable checking of the VNGS format with regards to strength,

weakness, applicability, and limitations of the data format, and provide a means of enabling validation 160

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of a data file against the format specification.

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( g ) Data versioning and provenance

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Data versioning and provenance shall be documented. A complete chain of provenance traceable

from isolated biological material shall be available for VNGS. If an entry is deleted, its identifier should 165

AOAC Draft Standard – Version 09282022; Public Comment Revisions

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