ESTRO 36 Abstract Book

S567 ESTRO 36 _______________________________________________________________________________________________

received 70 Gy /35 fractions /7 weeks as per institutional protocol.

Results Out of 54 patients only 46 patients (85%) completed NACT. The most common side effect encountered during induction chemotherapy is nausea and vomiting representing 24%, followed by anorexia representing 20%. After completion of induction chemotherapy we had observed radiologically 24%, 63% and 13% as complete, partial and non-responders respectively. Acute toxicities like skin reactions,mucosal reactions, xerostomia, pharyngitis/ hoarseness, upper GI side effects, and hematological complications are more in Arm A than Arm B. Patients in arm B has tolerated the local radiation therapy compared to the patients in arm A. The quality of life of patients in arm B compared to arm A was appreciable during the local treatment. At 6 th month follow up local control, disease free survival, overall survival, found in arm Avs arm B was 45% vs 50%, 25% vs 35%, 85% vs 95% respectively. Progressive disease and lost to follow up was 15% vs 10%, 10% vs 5% respectively. Patients died in arm A vs arm B was 5% vs 0% respectively. Late radiation toxicities were assessed clinically at 6 months as per RTOG criteria and results had found not statistically significant.

Conclusion As observed in our study, 40 patients out of 54 has been down staged. Symptoms like swallowing, anorexia, tumor related pain, weight loss has been improved after induction chemotherapy. However, this study definitely showed down staging and better treatment tolerance towards IMRT arm in locally advanced oropharyngeal carcinoma. A long term study for longer follow up required for any statistically significant result. Better response can be expected in early stage disease EP-1028 MRI during radiotherapy: tumor geometry and changes in organs at risk for head-and-neck patients C. Grundmann 1 , K.A. Kessel 1,2 , S. Pigorsch 1 , S. Graf 3 , F. Nüsslin 1 , S.E. Combs 1,2 1 Technische Universität München TUM, Department of Radiation Oncology, München, Germany 2 Helmholtz Zentrum München, Institute for Innovative Radiotherapy iRT, Neuherberg, Germany 3 Technische Universität München TUM, Department of Otorhinolaryngology, München, Germany Purpose or Objective The use of image-guided radiotherapy (IGRT) leads to a protection of OARs and a resulting reduction of side effects for the patient. The aim of this work is to make a statement about the relevance of MRI during radiotherapy (RT) and illustrate the importance for radiation oncology. Material and Methods In a retrospective analysis, for 17 patients with head-and- neck-cancer, the volume of eight OARs relevant for swallowing was examined on MRI. Contouring was performed on MRI before, during and after radiation and the dose applied to the OARs was determined. Five of the 17 patients additionally participated in a voice and swallowing test on average 22.2 months after RT. Three questionnaires (Anderson Dysphagia Inventory (ADI-D), Voice Handicap Index, EORTC QLQ-H&N35) were used to evaluate subjective voice and swallowing disorders and the related quality of life. Additionally, fiberoptic endoscopic evaluation of swallowing (FEES) and a voice test were performed, including the assessment of the patient’s phonation and