Dechra Brand Guidelines

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Common Clinical signs • Lethargy,weakness, exercise intolerance • Weightgain • Alopecia • Seborrhoea • Pyoderma • Hyperpigmentation • Neuropathy • Vestibular syndrome • Female infertility • Myxoedema (“Tragic” faces) •Lipid keratopathy

What is canine hypothyroidism?

• 50%of cases aredue to lymphocytic infiltration anddestructionof the thyroidgland. Themajorityofother cases are causedby idiopathic thyroid atrophy i . • Hypothyroidism affectsbetween0.2 – 0.6%ofdogs ii . • Most common inmiddle ageddogs, certainbreeds aremoreprone. • Clinical signs are insidious,developingovermonthsor even years,oftenmistaken for the ageingprocess. • Correctdiagnosismaybe challenging as symptoms are vague,no test available is 100% accurate and frequentlyusedmedications and non-thyroidal illness can affect thyroid hormone levels.Treatmentof hypothyroidism is however straightforward.

The day they can control hypothyroidism isn’t far away.

Thyroid hormone overview • A typical negative feedback systemgoverns the amountof thyroid hormone (T4 andT3) secreted by the thyroidgland. • Secretion ismainly regulatedby the stimulating effectofTSH. • TSH stimulates the releaseofT4 andT3 from the thyroidgland. • TSH enhancesdeiodinationofT4 intoT3 in the thyroidgland. • Inprimary hypothyroidism,TSH levels tend tobe high but in 25%of cases theymay remain at normal levels iv .

Hypothalmus

+

TRH

--

+ Pituitary

TSH

--

ThyroidGland

T4

T3

Hormone levels are influenced by:

The improvement can happen in weeks. The positives can last a lifetime.

Adapted from Daminet.S. (2002)

• Age • Sex • Breed • Weight • Oestrus cycle • Medication • Concurrentdisease

BETTERTIMESAHEAD