Dechra Brand Guidelines

The importance of treatment

Treatment with Vetoryl

Now that yourdog has started treatment, you should soon notice somemarked improvements. It is important that you follow the instructionsgivenby your veterinary surgeon.

Treatment improves yourdog’squalityof life and prevents thedevelopmentofother,potentially life-threatening, conditions forwhich treatment canbe intensive and costly. Cushing’s syndrome has a large, negative impacton yourdog’squalityof life and if left untreated your dog runs agreater riskof serious conditions such as:

YourdogwillbeginVetoryl at the recommended startingdosebasedon itsbodyweight.You should thenmake an appointment for yourdog to return to your veterinary surgeon after 10days. If necessary, your vetmay have to adjust thedosageofVetoryl.Everydosage change should againbe followedby a check up after 10days.

Your veterinary surgeonwill assess yourdog’s response toVetoryl treatmentby:

• Looking for improvement inclinical signs Inmost cases you can expect to see adecrease in yourdog’s appetite and the amount they drinkwithin the first coupleofweekson treatment.Other clinical signsmay take 3 to 6months to improve. • Performingblood tests The resultsof routineblood tests and anACTH stimulation test are used to assess the effectiveness ofVetoryl treatment at 10days, 4weeks, 12weeks and every 3months after starting treatment.

• diabetesmellitus • highbloodpressure

• pancreatitis (inflammationof thepancreas) • infectionsof the kidneys and urinary tract • pulmonary thromboembolism (blood clots in the lung)

Always use the additional energy light effects sparingly.

Management of Cushing’s syndrome Cushing’s syndrome cannotbe cured,but it canbe successfullymanagedusingmedication. Vetoryl®,which is theonly licensed treatment for use indogs, contains the active ingredient trilostane, adrugwhich reduces theproductionof cortisolby the adrenalglands.

Don’t be tempted to use them on every page as they become too dominant, they’re designed to create a visual flow through the various materials but they are not our key images.

Justasmedical treatmentcanunmaskallergicdermatitis, itmayalsounmaskor intensify symptomsofosteoarthritis. Adietwith increased levelsofomega-3 fattyacidscan supporthealthy jointsandmobility 5 . Bloodglucose levels indogswithhyperadrenocorticismare often in thehighendof the reference rangeandabout10% of thedogswithhyperadrenocorticismdevelopovertdiabetes mellitus 6 .Poorcontrolofbloodglucose iscausedby antagonismof insulinby thegluconeogeniceffectsofexcess glucocorticoids.Althoughmedical treatmentof hyperadrenocorticism significantly reducesplasma levelsof cortisol, thiseffectmaynot last throughout thewholeday, whichmayexplain the lackofcontrolofbloodglucose in somedogs. Nutritionalmanagementcanplayan important role in themanagementofhyperglycemia.High-fibrediets withcomplexcarbohydratescan reducepost-prandial glucose levels 7 andhigh levelsofomega-3 fattyacidscan improve insulin sensitivity in insulin resistantdogs 8 . Although increased levelsofblood lipidsare reducedby Vetoryl ® treatment,blood lipid levelscan remain increased. Hypertension isanotherdisease thatmaynotbecompletely prevented inalldogswithhyperadrenocorticism treatedwith Vetoryl.High intakeofomega-3 fattyacidscanhelp to regulatehyperlipidemia 9 and supportmaintenanceofnormal bloodpressure. Hyperadrenocorticism ismainlydiagnosed inelderlydogs. Inelderlydogshealthproblems likeobesity, reducedheart andkidney functionand reduced immune statusaremore prevalentand theseanimalscouldbenefit fromadditional nutritionalmanagementwithadietwithamoderateenergy density,moderate levelsofphosphorusand sodiumand added taurine,L-carnitine,omega-3 fattyacidsand beta-glucans. Appropriatedietaryadvice shouldbegivenaccording to theconditionof thedogwithhyperadrenocorticismand thepresenceof intercurrentdisease. It is recommended tocontinuemonitoring thenutritional statusof thedogand presenceofpotentialconcurrentcomplicationsand to adapt thenutritionalmanagement foreach individualdog asneeded.

1.WSAVANutritionalAssessmentGuidelinesTaskForce Members (2011)WSAVANutritionalAssessmentGuidelines. Journalof SmallAnimalPractice 52: 385-396.

CEDENDOCRINESUPPORT

2.HenselP (2010)Nutritionand skindiseases in veterinary medicine. ClinicalDermatology 28: 686-693.

Medical treatment is thecornerstoneofendocrine disordermanagement,butoptimalnutritional support canbean importantadjunct in today’s veterinaryclinic. Endocrinedisorders suchashyperadrenocorticism, hypothyroidismanddiabetesmellitus impactmany organsandbody functionsandareoftenaccompaniedby complications suchaspoor skinconditions,poorglucose control, recurrent infections,hyperlipidemia,hypertension oroverweight.SPECIFIC TM CEDEndocrineSupporthas been specially formulated toprovideadditionalnutritional support tomedical treatmentofendocrinedisorders.

3.LiJ etal . (2006)Effectsofbeta-glucanextracted from Saccharomycescerevisiaeongrowthperformance,and immunologicaland somatotrophic responsesofpigs challengedwithEscheriacoli lipopolysaccharide. Journalof AnimalScience 84 :2374-2381. 4.Baddaky-TaugbølB etal . (2005)A randomised,controlled, double-blinded,multicentre studyon theefficacyofadiet rich infishoilandborageoil in thecontrolofcanineatopic dermatitis. InAdvances inVeterinaryDermatology,Vol. 5. Eds AHillier,APFoster,KWKwochka.Oxford,UK,Blackwell Publishing.pp173-187. 5.RoushJK etal . (2010)Multicenter veterinarypractice assessmentof theeffectsofomega-3 fattyacids in osteoarthritis indogs. Journalof theAmericanVeterinary MedicalAssociation 236: 59-66. 6.HerrtageME&Ramsey IK (2012)Canine hyperadrenocorticism. InBSAVAManualofCanineandFeline Endocrinology.4thedn.EdsCTMooneyandMEPeterson. BritishSmallAnimalVeterinaryAssociation.pp167-189. 7.GrahamPA etal . (1994)Cannedhighfiberdietand postprandialglycemia indogswithnaturallyoccurring diabetesmellitus.JournalofNutrition 124: 2712S-2715S. 8.LeBloc’hJ etal . (2010)Omega-3 fattyacids supplementation improves insulin sensitivityand increases EPAandDHA tissuecontent inobese insulin resistantdogs. InTheWaltham InternationalNutritionalSciencesSymposium PetNutrition-ArtorScience?Cambridge,UK,September 16-18,2010,pp38. 9.BaysHE etal . (2008)Prescriptionofomega-3 fattyacids and their lipideffects:physiologicmechanismsofactionand clinical implications. ExpertReviewofCardiovascularTherapy 6: 391-409.

Cerealswitha reducedglycemic index (wholewheatandoats)anda high leveloffibre topromotegradual releaseofglucose from thediet to reducepostprandialhyperglycemia for supportofpatientswithdiabetes mellitusorpoorbloodglucosecontrol.

Fibre

Diabetes mellitus

Glycemic index

Uniquelyhigh levelsofomega-3 fattyacidsEPAandDHA fromfishoil andomega-6 fattyacidGLA fromborageoil. High intakeofomega-3 fattyacidshas shown to regulateblood lipids incaseofhyperlipidemia,helpmaintainnormalblood pressureand increase insulin sensitivity.These fattyacidscanaffect the immune response andalter theproductionofeicosanoidswhichhaveeffectsondifferentprocesses in thebody.

Immune support, regulation blood lipids

EPA DHA

GLA

Contains ß-1,3/1,6-glucans from yeast,and increased levelsof zinc, seleniumandomega-3 fattyacids to support the immune status. Beta-glucanscanbind tomacrophagesandalert the immune system, thereby supporting the immune responseandalteringcytokineproduction.

Immune support

Acomplete,balanceddietwith verymoderateenergydensity for supportofoptimalweightmanagement.The controlled levelsofminerals likephosphorusand sodium reduce theworkloadof thekidneysand support renal function in seniordogs.

Moderate energy, balanced minerals

Contain EPAandDHA fromfishoil for supportofhealthy joints, skinandcoat.

Joint, skin & coat support

<< Back to Contents