Dechra Brand Guidelines

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Treatment

There are three established treatmentoptions for felinehyperthyroidism:

• The first veterinary-licensedmedical treatment for feline hyperthyroidism inEurope • Contains the anti-thyroiddrug thiamazole • Dose is independentofbodyweight andof the totalT4 concentration atdiagnosis • Indicated for long-term treatment and stabilisationprior to surgical thyroidectomy • Reversibly inhibits the enzyme thyroidperoxidase to control excessiveproductionofT3 andT4

• Medicalmanagement to reversibly inhibit synthesisof thyroidhormones • Surgical thyroidectomy to remove the abnormally functioning thyroid tissue • Radioactive iodine therapy todestroy the abnormally functioning thyroid tissue

Medical management

Radioactive iodine therapy

Surgical thyroidectomy

CAPILLARY LUMEN

Hyperthyroidism. From diagnosis to treatment, precise control, every step of the way.

-

I (Iodide)

Active uptake

THYROID GLAND FOLLICLES

Limited numberof specialised centres

Skilled surgeon required

THYROID FOLLICLE CELL

T 4 T 3

Availability

Readily available

Thyroglobulin (Tg) production

-

I

-

I

Effective if ectopic hyperplastic thyroid tissue

No – ectopic tissue may notbe surgically accessible

Tg

Yes

Yes

T 4 T 3

+

I (free radical)

L

L

Iodinated

L

1 to 20weeks ii

Immediate, post-surgery Priormedical stabilisation recommended

Tg

Coupling

reaction

Time to achieve euthyroidism ii

Pinocytosis

THYROID FOLLICLE LUMEN

3 to15days ii

Priormedical stabilisation recommended

Tg T 4 T 3

Thyroid peroxidase

L = Lysosome

Reversible

Yes

No

No

• Small, sugar-coated tablets –designed for easeof administration • Two tablet strengths –2.5mg and 5mg – colour-coded for easydifferentiation • Available inpotsof100

Need forgeneral anaesthesia

Not required

Not required

Yes

1 to 10days ii (dependentonpost- operative complications)

Minimum 7days (dependanton centre)

Need for hospitalisation

Not required

Treatment failureor recurrenceof hyperthyroidism

Unlikelywith regular monitoring andgood owner compliance

Possible, even followingbilateral thyroidectomy iii

Rare

Possible iv .Canbe easilymanagedby reducingdoseof medication

Possible iv .May require supplementationwith thyroid hormones if prolonged

Possible iv .May require supplementationwith thyroid hormones if prolonged

Iatrogenic hypothyroidism

InitialCost ii

Low

High

Intermediate

Medical treatment is recommended for initial stabilisation,whichever long-term therapeuticoption is chosen v .

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