Quality Management 2017

How to set the Clinical tolerance limit ( TL  )?



Clinical tolerance limits or specifications should be based on clinical experience. Clinical experience can be summarized through statistical analysis of the outcome of a particular treatment for a particular tumor disease.





Examples:

 Local tumor control as a function of dose.

 Fraction of survivors after five years as a function of dose.

 At the same time, normal tissue complications must be taken into account.

T. From JörgenOlofsson (Dose Modeling and dose verification ESTRO COURSE)