AOAC CASP SMPRs for Comment

102 103 104 105 106 107 108

9. Maximum Time-To-Result: None

Table 1: Residual Solvents

Table 1: List of Residual Solvents and Targeted LOQs

Proposed Target LOQ (ppm)

Analytical Range

Concentration Limit (ppm)

Lower

Upper

1 2

1 2

30 60

Class 1 Residual Solvents*

2

Benzene

4

4

4

120

Carbon tetrachloride

5

5

5

150

1,2-Dichloroethane 1,2-Dichloroethane

1870

8

8

8

240

1,1-Dichloroethene

1870

1,1-Dichloroethene 1,1,1-Trichloroethane

1500

1500

1500

45000

Class 2 Residual Solvents* Acetonitrile

410

410

12300

410

acetonitrile

6

360

360

10800

Chlorobenzene

360

60 70

60 70

1800 2100

Chloroform

60 70

Cumene

3880 1870

3880 1870

116400

Cyclohexane

3880 1870

56100

1,2-Dichloroethene 1,2-Dimethoxyethane N,N-Dimethylacetamide N,N-Dimethylformamide

100

100

3000

100

1090

1090

32700 26400 11400

1090

880 380 160 620 220 290

880 380 160 620 220 290

880 380 160 620 220 290

1,4-Dioxane

4800

2-Ethoxyethanol Ethylene glycol

18600

6600 8700

Formamide

Hexane

n-hexane Methanol Methanol

60

3000

3000

90000

3000

400

50 50

50 50

1500 1500

2-Methoxyethanol Methylbutylketone Methylcyclohexane

50 50

1180

1180

35400

1180