Brain Tumours

Intraoperative stimulation mapping cinical relevance

De Witt Hamer PC, Gil Robles S, Zwinderman AH, et al. Impact of & intraoperative stimulation brain mapping on glioma surgery outcome: a meta-analysis. J Clin Oncol 2012; 10:2559 – 2565.

Meta-analysis including 8091 patients Late Severe Neurological Deficits observed in 3.4% of ISM vs 8.2%

“ Glioma resections using ISM are associated with fewer late severe neurologic deficits and more extensive resection, and they involve eloquent locations more frequently. This indicates that ISM should be universally implemented as standard of care for glioma surgery ” .