AOAC-RI ERP Book Micro Jan 19 2017

Table 5. POD CP , POD CC , and dPOD CP Values for the Candidate Method (200 g Spinach Analyzed via the 3M TM MDA) and POD R , POD C , and dPOD C Values for Candidate Method vs. the Reference Method (200 g Spinach Analyzed via the FDA BAM Ch. 4A)

Method / Inoculation Level

Measure Value

95% CI

POD CP POD CC dPOD CP POD CP POD CC dPOD CP POD CP POD CC dPOD CP

1.000 (0.5655, 1.000) 1.000 (0.5655, 1.000) 0.000 (-0.434, 0.434) 0.350 (0.1812, 0.5672) 0.350 (0.1812, 0.5672) 0.000 (-0.275, 0.275) 0.000 (0.000, 0.4345) 0.000 (0.000, 0.4345) 0.000 (-0.434, 0.434) 1.000 (0.5655, 1.000) 1.000 (0.5655, 1.000) 0.000 (-0.434, 0.434) 0.450 (0.2582, 0.6579) 0.350 (0.1812, 0.5672) -0.100 (-0.368, 0.190) 0.000 (0.000, 0.4345)

Candidate Method Screening vs. Confirmation High Level Inoculation

Candidate Method Screening vs. Confirmation Low Level Inoculation

Candidate Method Screening vs. Confirmation Un-inoculated

POD R POD C

Reference Method vs. Candidate Method High Level Inoculation

dPOD C

POD R POD C

Reference Method vs. Candidate Method Low Level Inoculation

dPOD C

POD R POD C

Reference Method vs. Candidate Method Un-inoculated

0.000 (0.000, 0.4345)

dPOD C

0.000 (-0.434, 0.434)

POD CP , Probability of Detection for Candidate Method “Screening Stage” Positive Results; POD CC

, Probability of

Detection for Candidate Method “Confirmation Stage” Results; dPOD CP of Detection for Reference Method Confirmed Results; POD C

, POD CP

Minus POD CC

; POD R

, Probability

, Probability of Detection for Candidate Method

Confirmed Results (i.e. Combined “Screening Stage” and “Confirmation Stage” Results); dPOD C , POD R Minus POD C . 95% Confidence Interval Values are Generated from the AOAC International POD Calculator.

CONFIDENTIAL INFORMATION Page 10 of 17