000000_Synthonics_ChyloCureBook_Rev031919

Improved Bioavailability (BA) and Efficacy of Chylobinoids and Mg-CBDa • Chylobinoids – Lipophilic nature may reduce first-pass hepatic metabolism and thus increase bioavailability by 2-5 times – Contain primarily CBDa, with other cannabinoid materials to promote “entourage effect” • Mg-CBDa (magnesium CBDa complex)

– CBDa believed to be substantially more potent (1000-4000x) than CBD in regards to receptor affinity – Magnesium coordination improves bioavailability by increasing amphiphilicity of complex – Possible synergistic CNS activity through NMDAR antagonism by magnesium ion