BispebjergHospital_1913-38

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sikkert langt mere hyppig end almindelig antaget, men ved den sæd­ vanlig anvendte routinemæssige behandling a f perniciøs anæmi med lever- eller ventrikelpræparater vil den ofte forblive ubemærket, da de almindelige lever- og ventrikelpræparater selvfølgelig også er virk­ somme ved den exogene form. Der findes antagelig alle overgange mellem den rent exogene re­ versible form og den rent endogene irreversible form, således at det utvivlsomt kun er en gradsforskel og et tidsspørgsmål om den ene eller den anden form udvikles. Rent praktisk har det betydning at afgøre om anæmien er reversibel eller ej, idet man i de rent exogene tilfælde kan spare patienterne for en gennem hele livet fortsat unø­ dig, men derfor ikke mindre besværlig og bekostelig behandling. A case of pernicious anæmia is reported in a man, aged 43 . It is shown that the development of anæmia is due to deficiency of »ex­ trinsic factor«, continuous during 7 —8 years. Treatment with »ex­ trinsic factor« exclusively is followed by complete recovery and com­ plete restoration of acid secretion in the stomach. The patient is controlled during 7 months subsequent to the discontinuation of the specific treatment, and no relapse is observed. The case is conceived as a case of »exogenous« pernicious anæmia, its etiology and pathogenesis are discussed, as well as its relation to true »endogenous« pernicious anæmia. References. 1. Alsted, G.: A cta Medica Scand. 1934, 82, 288. — 2. Alsted, G.: The L ancet 1937 x, 76. — 3. Castle, W. B .: Am. J . Med. Sci. 1929, 178, 748. 4. Castle, W B Heath, C. W. 6s Strauss, M . B .: ibidem 1931, 182, 741. — 5. Castle, W. B.'db Townsend, W. C.: ibidem 1929, 178, 764. — 6 . Castle, W. B„ Townsend, W. C. & Heath, C. W .: ibidem 1930, 180, 305. — 7. Connery & Joliffe. ibidem 1931 181 830. — 8 . Groen, J . A Snapper, I .: ibidem 1937, 1 3, 633. 9. Hurst, A .’ f .: G uy’s Hosp. Rep. 1930, 80, 407. — 10. Hurst, A . F .: Q uart. J . Med. 1932, 25, 197. — 11. Jones, C . M ., Benedict, E. B. & Hampton, A . O.. Am. J . Med. Sci. 1935, 190, 596. — 12. Lunn, V.: A cta Medica Scand. 1938, 94 588. — 13. Magnus, H. A . 6s Ungley, C. C.: The L ancet 1938, J , 420. — 14! Meulengracht, E .: Proceed. R oyal Soc. Med. 1935, 28, 37. — 15. Meulen- qracht, E .: The L ancet 1937, I, 1404. — 16. Seyderhelm 6s Opitz: K lin. W -schr. 1928, 7, 205. — 17. Ungley, C. C.: Q uart. J. Med. 1933, 2, 381. 18. Ungley, C. C.: The L ancet 1938, I, 925. — ]9. Wills, L .: B rit. Med. J . 1931, I, 1059. Summary. Exogenous Pernicious Anæmia.