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Otolaryngology–Head and Neck Surgery 148(6)

assessment of disease involvement by CT and MRI remains valuable. Although the extent of anatomical involvement does not reliably predict outcome, those with clival involve- ment indicating central skull base osteomyelitis were noted to do much poorer with conventional treatment, and this should be explored in future studies. The choice of antibio- tic therapy is difficult in culture-negative cases in view of increasing reports of antibiotic resistance in P aeruginosa , but our outcomes with empirical combination therapy using intravenous ceftazidime and oral fluoroquinolone suggests that this regime remains effective.

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Author Contributions

Shaun Loh , data collection, entry, analysis and writing of manu- script; Woei Shyang Loh , study idea, advice on analysis, review of manuscript.

Disclosures Competing interests: None. Sponsorships: None. Funding source: None.

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