HSC Section 8_April 2017

Crowson et al

Table 3. (continued)

Study

Outcome Measures

Hearing Result

Vertigo Result

Side Effects

Study Quality

improvement . 10 dB

Nozawa et al (1995) 19 1972 CHE reporting guidelines, PTA

Some patients

4

Definitive episodes were successfully controlled in 15 of 20 (75%); of 10 who were given drug intermittently, definitive episodes were successfully controlled in 6 of 10 (60%; according to the AAOO) and 7 of 10 (70%; according to AAO-HNS criteria) Vertigo symptoms well controlled in 8 of 12 (67%) 29% complete control of vertigo, 42% improved vertigo. 50% normalization of ECoG A significant change in Dizziness Handicap Inventory score and prominent changes observed in functional scores

Hearing improved in 6 of 30 (20%), remained unchanged in 18 of 30 (60%), and became worse in 6 of 30 (20%); tinnitus disappeared in 5 of 30 (16.7%) and improved in 10 of 30 (33.3%); effectiveness rate for tinnitus was 50% (15 of 30 patients) Hearing stabilized or improved in 7 of 12 (58%) Hearing unchanged in 71%, hearing worsened in 29% Hearing improved in 33.3% of 2-y group, 26.7% of 4-y group, 20% of 6-y group, and 16.7% of the 8-y group; initial hearing preserved in 59.3%, 63.3%, 50%, and 16.7% in each group; hearing preserved or improved in 70%- 92% of 2, 4, and 6-y groups, but 4

complained of abdominal discomfort

Lassen et al (1996) 17

1972 CHE reporting guidelines, PTA

1 with gastrointestinal upset,

4

Kitahara et al (2004) 15 Japan Society for

None reported

4

Equilibrium Research for Me´nie`re’s disease, ECoG

Chung et al (2010) 13

None reported

4

Dizziness Handicap Inventory, PTA

(66.7%) showed aggravation in 8-y group

Eryaman et al (2012) 25 EEVS, VHQ, vestibular testing (oculomotor, Dix-Hallpike, calorics)

Not reported

Significant decrease in score of EEVS and

None reported

3b

VHQ at 3 wk compared to baseline

Abbreviations: AAO-HNS, American Academy of Otolaryngology—Head and Neck Surgery; AAOO, American Academy of Ophthalmology and Otolaryngology; CHE, Committee on Hearing and Equilibrium; ECoG, electrocochleography; EEVS, European Evaluation of Vertigo Scale; PTA, pure tone average; VHQ, Vertigo Handicap Questionnaire.

of action for the diuretics reviewed vary ( Table 7 ), but a common theme involves regulation or modulation of ion transport across membranes. The pathophysiology of MD is

aggregated results. A majority of these studies reported improvement in vestibular symptoms or vertigo, with less than half reporting improvement in hearing. The mechanisms

30