Abstract book - ESTRO meets Asia

S98 ESTRO meets Asia 2018

free survival (DFS), distant failure (DF) and para-aortic lymph nodes failure (PALNF) between PRT and EFRT

groups. Results

A total of 778 patients were analyzed. Of them, 624 patients were treated with PRT and 154 patients received EFRT. The median follow-up period was 37.5 months. In multivariate analysis, EFRT was an independent prognostic factor of DF (HR 0.49, 95%CI 0.26-0.90, p=0.023) and PALNF (HR 0.012, 95%CI 0.00-0.49, p=0.019). However, it is not significant in predicting OS (p=0.546) and DFS (p=0.187). With propensity-score matching, 108 pairs of patients were selected. The 3-year OS, DFS, DF and PALNF rates in PRT and EFRT groups were 87.1% and 85.7% (p=0.681), 71.0% and 80.6% (p=0.199), 21.7% and 7.0% (p=0.016), 6.6% and 0% (p=0.014), respectively. The incidences of ≥grade 3 chronic toxicities were 3.5% and 6.5% in PRT and EFRT groups(p=0.097). Conclusion Prophylactic EFRT was associated with decreased DF and PALNF, and had a trend to improve DFS in cervical cancer patients treated with CCRT. PO-238 Comparisons between young and elderly patients with cervical cancer treated with chemoradiotherapy W. Wang 1 , K. Hu 1 , F. Zhang 1 1 Peking Union Medical College Hospital, Radiation Oncology, Beijing, China Purpose or Objective To compare the survivals and toxicities of young and elderly cervical cancer patients treated with definitive radiotherapy or concurrent chemoradiotherapy (CCRT). Material and Methods Cervical cancer patients treated with radiotherapy or CCRT between January 2010 and December 2015 in our institute were reviewed. A dose of 50.4Gy in 28 fractions was delivered to the pelvic with intensity modulated radiation therapy. And a dose of 30-36Gy in 5-7 fractions was prescribed to point A with brachytherapy. Weekly cisplatin was the first line regimen of concurrent chemotherapy. Comparisons were made between patients in young group (<60 years) and elderly group (≥70 years) with multivariate analysis and propensity score matching. Results There were 991 patients in young group and 70 patients in elderly group. The median follow-up period was 30.2 months. In multivariate analysis, age was an independent factor of overall survival (OS, hazard ratio, HR 1.99, p=0.014), but it was not significant in predicting disease- free survival (DFS, HR 1.41, p=0.179) and cancer-specific survival (CSS, HR 1.38, p=0.332). After propensity score matching, 64 pairs of patients were selected. The 3-year OS, DFS and CSS rates in young and elderly groups were 86.5% and 73.9% (p=0.280), 74.6% and 75.4% (p=0.744), 87.9% and 81.7% (p=0.967), respectively. Significant differences between young and elderly group were observed in ≥ grade 3 chronic toxicities (2.9% and 8.6%, p=0.027) and ≥ grade 3 chronic gastrointestinal toxicities (2.4% and 8.6%, p=0.009).

Conclusion After definitive radiotherapy or CCRT, the DFS and CSS of elderly patients with cervical cancer were similar with young patients. Elderly patients experienced more chronic toxicities than young patients. PO-239 Comparison between squamous cell carcinoma and adenocarcinoma of cervix after chemoradiotherapy W. Wang 1 , K. Hu 1 , F. Zhang 1 1 Peking Union Medical College Hospital, Radiation Oncology, Beijing, China Purpose or Objective Concurrent chemoradiotherapy (CCRT) is efficacy in the treatment of locally advanced cervical squamous cell carcinoma (SCC). However, it was conflicting issue whether treatment outcomes of cervical adenocarcinoma were equivalent to SCC after CCRT.In the present study, we analyzed the prognostic significance of adenocaricinoma. Material and Methods Medical records of cervical cancer patients treated with definitive radiotherapy or CCRT in our institute from January 2011 to December 2014 were reviewed. Patients were treated with intensity modulated radiation therapy. PO-240 CT based intra-cavitary brachytherapy in cervical cancer: an economically feasible alternative?! V. Ikkurthi 1 , A. Uday Krishna 1 , C. Tanvir Pasha 1 , P. Sridhar 1 , V. Lokesh 1 1 Kidwai Cancer Institute, Radiation Oncology, Bangalore, India Purpose or Objective Magnetic resonance imaging (MRI) based intra-cavitary brachytherapy (ICBT) is the current standard of care in the brachytherapy of carcinoma cervix(ca cervix). In our study we tried to evaluate the accuracy of Computerized tomography(CT) based ICBT as an economically feasible and faster alternative to the standard approach. Material and Methods 22 patients with locally advanced carcinoma cervix registered in the department of radiation oncology, Kidwai Cancer Institute, Bangalore, were enrolled in the study. After an informed consent each patient underwent examination under anesthesia(EUA),a pre External beam radiotherapy(EBRT) MRI ,cystoscopy and proctoscopy if indicated. All the patients received radical radiotherapy with 6MV photons to a dose of 45Gy in 25 fractions with weekly platinum-based chemotherapy given concurrently.