Abstract book - ESTRO meets Asia

S67 ESTRO meets Asia 2018

Purpose or Objective Adjuvant radiation therapy (RT) is the standard therapy in patients affected by primary brain tumors (BT); Radiotherapy sometimes induces side effects that could influence patients’ quality of life (QoL). Moreover BT cause significant distress, anxiety and depression. In our Department a Psycho-Oncological Support Service is available. Aim of this study is to evaluate the impact of psychological support on distress, mood (anxiety/ depression) and QoL during RT and after three months in these patients. Material and Methods Brain tumor patients were followed by a psycho-oncologist for the whole RT course. Distress Thermometer (DT), Hospital Anxiety and Depression Scale (HADS) and Functional Assessment of Cancer Therapy (FACT-Br) were administered at the beginning (t0), middle (t1) and at the end of RT (t2). A final interview was performed three months after RT (t3). Psychological support was customized on psychological profile and patients’ needs. Statistical analysis of time variations in tests’ scores was performed by the Wilcoxon signed-rank test; the relationship between clusters of psychological profile and dichotomic survival performance by a Fisher's exact test. Overall Survival (OS) was investigated with Kaplan Meier curves and Log-Rank test. Results From January 2016 to April 2017, sixty consecutive patients (34M 26F, median age 55) were analyzed. Forty- seven out of patients (78.3%) received RT with concurrent Temozolomide while 13 (21.7%) RT alone. Median total dose was 60 Gy (range 54-60) For psychological profile at t0 we identified 2 groups: 'easy patients” (EP) (DT<4;HADS<14)(27 pts) and 'uneasy patients” (UP) (DT≥4 and/or HADS≥14)(33 pts). In EP we did not observe any significant statistical change over time. In UP we found a statistically significant improvement in DT and HADS when comparing t1 vs tT2 (p<0.001). Emotional and functional wellbeing (FACT-Br) improved over time (t0 Vs t3) (p<0.001). "Uneasy patients” received more psychological sessions that EP. Evaluating the course of DT and HADS scores during RT in relationship with sessions’ number (3, 4 or ≥5) we observed that DT scores of UP group had a slightly significant improvement in all three conditions (fig. 1). For glioblastoma (GBM) patients, the OS was related to psychological profile ('easy patients” had longer survival than 'uneasy patients”) (p-value=0.002 at the log- rank test on Kaplan Meier curves) (fig. 2). Remarkably, there is no evidence of correlation between 'easy”/”uneasy” condition at t0 and age/histology/sex or residual.

Conclusion Our study shows that ”uneasy patients” improve in distress, mood and QoL with psychological support whereas in ”easy patients” the psychological support preserves the psychological well-being. In GBM, psychological profile at t0 is candidate to be a possible predictor of the OS after 12 months. These results encourage us to standardize a psychological support model for all RT patients. PO-167 Clinical outcome of high-grade glioma in a tertiary cancer hospital of Bangladesh: 1 year experience A.R. Chowdhury 1 , M.R. Sharif 1 , M.S.S. Alam 1 , N. Rukhsana 1 , M.M.S. Hossain 1 , L. Nahar 1 , M.M. Huda 1 , P.A. Banu 1 1 Delta Hospital Limited, Oncology, Dhaka, Bangladesh Purpose or Objective High grade gliomas, specifically Glioblastoma multiforme (GBM) is the most common and most aggressive primary brain tumour in adult. Despite significant research into identifying prognostic and predictive biomarkers and even with the refinement in treatment approaches in the past decades, the outcome of GBM has not improved significantly. Prognosis of GBM remains poor, with a median survival time of around 15-months. The aim of this study is to assess the clinical outcomes in patient with high grade glioma. Material and Methods We conducted a retrospective audit of high-grade glioma patients in our tertiary-level cancer hospital in Dhaka, Bangladesh from 1 st January 2015 to 31 st December 2015. Data were collected and analyzed using simple, descriptive statistics regarding demography, disease and treatment outcome.