Abstract book - ESTRO meets Asia

S78 ESTRO meets Asia 2018

comparable. Dose constraints were better achieved in SIB, for esophagus and C/L lung ( p= 0.003, 0.03 respectively). Conclusion In this study HI was better with SIB than SB with comparable coverage. Doses to esophagus and C/L lung were significantly reduced with SIB technique. However, dose to heart was similar in both the techniques with no variation in heart dose with laterality of BC. PO-193 Prognostic factors in locally advanced breast cancer with HER2+/HR- with NAC followed by PMRT. Y. Kumai 1 , N. Nakajima 1 , H. Inoda 1 , Y. Yoshioka 1 , M. Oguchi 1 1 Cancer Institute Hospital, Radiation Oncology, Tokyo, Japan Purpose or Objective The aim of this study was to determine clinical outcomes and identify reliable prognostic factors in patients with locally advanced breast cancer who had HER2 positive and hormone receptor (HR) negative subtype treated with neoadjuvant chemotherapy (NAC) followed by We retrospectively evaluated the relationship between clinicopathological factors and clinical outcomes in 55 patients with HER2 positive and HR negative, stage II or III breast cancer who underwent NAC followed by radical mastectomy and PMRT between March 2005 and December 2013. Locoregional recurrence free survival rate (LRFS), distant metastasis free survival rate (DMFS), and overall survival rate (OS) were calculated as clinical outcomes. Results he median follow-up duration was 87 months. All patients were treated with trastuzumab. Seven patients experienced locoregional recurrence, 16 patients experienced distant failure, and 13 patients died of cancer. For all patients, the 6-year LRFS, DMFS, and OS were 87.1%, 70.0 %, and 83.0 %, respectively. Pathological CR rate was 31.0 %. On multivariate analysis, nodal ratio (NR; number of positive axillary node/removed node) were significant prognostic factors of LRFS (HR 13.2, 95 % CI 1.26-135.97, p =0.03), and nuclear grade (NG) had a tendency to correlate with DMFS and OS (HR 0.19, 95 %CI 0.010-1.083, p =0.06) (Cox regression analysis). The patients with low NG (NG1/2) had significantly better 6- year OS than patients with high NG(NG3) (95.5 % vs. 72.0 %, p = 0.02), and patients with low NR (NR<30) had significantly better 6-year OS than patients with high NR (NR ≧ 30) (90.1 % vs. 50.0 %, p=0.003). The 6-year OS was significantly better in patients with pCR than those with non- pCR(94.1 % vs. 71.4 %, p=0.03) (log-rank test). Conclusion We identified several prognostic factors in our patients; in particular, NG, NR and pCR were significantly related to OS. PO-194 Assessment of cosmesis, quality of life in patients who have undergone breast conservation therapy D.C. Ramalingam 1 , D.G. Karunanidhi 1 , D.K. Dharanipragada 2 , D.P. Penumadu 3 , D.J. Das 1 1 JIPMER, RADIATION ONCOLOGy, Puducherry, India 2 JIPMER, General Surgery, Puducherry, India 3 JIPMER, SURGICAL ONCOLOGy, Puducherry, India Purpose or Objective Among patients with breast cancer who have received breast conservation therapy in JIPMER, • To measure the cosmesis using an objective method – BCCT.CORE software, following breast conservation therapy (BCT). • To assess the quality of life (QOL) using (European Organization for Research and Treatment of Cancer) mastectomy and PMRT. Material and Methods

EORTC BR23 and C30 questionnaire for patients who underwent breast conservation therapy. • To correlate the impact of cosmesis on quality of life. Material and Methods We conducted a cross sectional observational study on patients who have completed BCT (at least 3 months post BCT). A photo will be taken of the breasts of the patient without the face of the patient thus taking care of their privacy using a camera specifically used for this purpose by the investigator. The photo is then assessed using the BCCT.CORE software to give the aesthetic result dichotomized into two categories – Excellent/Good and Fair/Poor expressed as percentage. QOL evaluated by EORTC C30, BR23 questionnaires was expressed as scores ranging from 0 to 100. The impact of cosmesis on QOL was assessed using Spearman Rank correlation test.QOL evaluated by EORTC C30, BR23 questionnaires was expressed as scores ranging from 0 to 100. The impact of cosmesis on QOL was assessed using Spearman Rank correlation test. Picture showing assessment of quality of life by BCCT CORE software.

Results About 2/3 rd of the patients had excellent/good cosmesis. 1/3 rd of the patients had fair/poor cosmesis. QOL was excellent/good for 59% of patients and fair/poor for 41% of patients. Cosmesis of the patient correlated well with quality of life with a positive correlation coefficient of +0.81 (close to 1) with a 2-tailed Significant value of 0.000(<0.05)

Majority of the patients post breast conservation therapy have a good cosmetic outcome and good quality of life. There is a significant positive correlation between the cosmetic outcome and the quality of life. Conclusion Hence BCCT.CORE software as an objective tool of assessment of cosmesis resulted in a more accurate assessment of cosmesis and thus leading to clear interpretation about the impact of cosmesis on quality of life. Hence, every attempt should be made to improve the cosmesis in every step of management of breast cancer patient as this will result in improvement of patient’s QOL. PO-195 Voluntary inspiration breath-hold technique in left- sided breast cancer radiation therapy in Asian W.L. Chan 1 , M. Lo 1 , J. Kong 1 , M. Szeto 1 , S. Ng 1 , A. Chan 1 , T. Lam 2 , M. Luk 1 1 Queen Mary Hospital, Clinical Oncology, Hong Kong, Hong Kong SAR China 2 The University of Hong Kong, Clinical Oncology, Hong Kong, Hong Kong SAR China