Abstract book - ESTRO meets Asia

S88 ESTRO meets Asia 2018

(45 Gy in 25 fractions @ 1.8Gy/fraction using 3DCRT technique), together with 5-fluorouacil and leucovorin (on the first 4 days and the last 4 days of radiotherapy). The European Organisation for Research and Treatment of Cancer Quality of Life (EORTC) Questionnaire QLQ C30 and STO 22 was assessed at four time points: pre and post chemoradiotherapy and at 1 month and 6 months follow up. Acute toxicity profile using the Common Terminology Criteria for Adverse Events (CTCAE) version 3 was also assessed. Repeated Measures of Analysis of Variance was used for statistical analysis of QOL. Results The mean age was 54.5 years and male: female ratio was 4:1. Stage II and Stage III disease was present in 60% and 30% of patients respectively. All patients were able to complete the chemoradiotherapy protocol. QOL levels decreased post chemoradiotherapy however they returned to baseline at 1 and 6 month follow up period. Our study found out significant impairment in QOL for emotional functioning, fatigue, nausea and vomiting and dysphagia. Among toxicities, 9 patients (30%) developed Grade II anemia and only 1 patient (3%) developed Grade III anemia. 6 patients (20%) developed Grade II Leucopenia and Grade III and Grade IV leukopenia was seen in 1 patient each (3%). Grade II and III thrombocytopenia was seen in 2 patients each (7%) while Grade IV thrombocytopenia was seen in 1 patient (3%). Radiotherapy interruption was seen in 4 patients, 3 patients with < 1 week duration and 1 patient with > 1 week duration. 12 patients (40%) developed nausea and vomiting (Grade I & II) while 5 patients (26.6%) developed diarrhoea (Grade I & II) during EBRT. Only 1 patient required Ryle Tube feeding while 7 patients required intravenous fluid administration. Conclusion Chemoradiotherapy using 3DCRT technique as adjuvant treatment for gastric cancer patients who have undergone resection with curative intent is a safe and well-tolerated regimen both with respect to Quality of Life and toxicity profile. PO-216 Gastric fundus irradiation dose not increased risk of anastomotic leakage in esophageal cancer Y. Kundel 1 , N. Kurman 1 , O. Sulimani 2 , S. Gavrieli 3 , H. Kashthan 2 , B. Brenner 4 , A. Popovzer 1 1 Beilinson Hospital, radiation oncology, Petach Tikva, Israel 2 Beilinson Hospital, surgery, Petach Tikva, Israel 3 Beilinson Hospital, radiology, Petach Tikva, Israel 4 Beilinson Hospital, medical oncology, Petach Tikva, Israel Purpose or Objective Standard of care in locally advanced esophageal carcinoma, is 3 -modality therapy: neoadjuvant chemoradiotherapy (nCRT) followed by esophagectomy - a surgical procedure which entails significant morbidity. Recent studies demonstrated post-surgical complications in 43% of patients. One of the notorious complications of esophagectomy is anastomotic leaks. Earlier studies suggested a correlation between the radiation dose to the gastric fundus, the part of the stomach used for anastomosis, on the risk of postoperative anastomotic leakage The aim of this study was to evaluate this correlation. Material and Methods We retrospectively reviewed the charts of 69 consecutive patients(pts) with middle/ distal esophagus and GEJ who underwent nCRT, followed by esophagectomy in 2008-2015. The chemoradiotherapy regiments consisted of 50.4 Gy in 28 fractions of 1.8 Gy with 5 FU and cisplatin or 41.4 Gy in 23 fractions of 1.8 Gy with weekly carbo and paclitaxel.

mutaions) ， 6 squamous cell carcinoma, 5 non-small cell lung cancer NOS (Not Otherwise Specified), 6 small-cell lung cancer, 2 primary malignant lung tumor of other types, 7 metastatic lung cancer and 2 benign diseases. Liquid withdraw technique assured adequate tissue for diagnosis and treatment planning of lung cancer. Among 86 cases diagnosed as malignant tumors, only 5 (5.8%) were diagnosed as NOS. Among 52 cases of adenocarcinoma who consented EGFR mutation test, only 1 case (1.9%)was failed due to insufficient tissue. Among all the biopsies, when cutting tumor tissue 4-6 times per procedure, the incidence of pneumothorax was in 18 cases (19.6%), among which 13 cases (14.1%) were very mild pneumothorax (lung surface retraction of≤1 cm), mild and moderate pneumothorax accounted for just 4.3%. No severe pneumothorax occurred and no case of pneumothorax required placement of a chest tube. 19 cases (20.7%) happened bleeding (18 cases were mild bleeding). No infection, tumor implantation or aeroembolism happened.

Conclusion CT-guided cutting-needle lung biopsy using co-axial and liquid withdraw is an accurate, safe ， reliable technique. Compared to lung biopsy without liquid withdraw, the incidence of pneumothorax was reduced from approximately 35% (reported by Tomiyama N et al. Eur J Radiol. 2006 Jul;59(1):60-4. A study of 9783 biopsies.) to 19.6% (14.1% were very mild pneumothorax and 0% were severe pneumothorax). The liquid withdraw technique also resulted in low rate of other complications and adequate tissue for diagnosis. Next, we are planning to conduct a prospective study to further evaluate the role of liquid withdraw technique in the precision diagnosis and treatment of lung cancer. chemoradiotherapy in gastric cancer patients D.S. Pruthi 1 , M. Ahmad 1 , M. Gupta 1 , S. Bansal 1 , V. Nautiyal 1 , S. Saini 2 1 Cancer Research Institute- Swami Rama Himalayan Univ ersity, Radiation Oncology, Dehradun, India 2 Cancer Research Institute- Swami Rama Himalayan Univ ersity, Surgical Oncology, Dehradun, India Purpose or Objective The primary curative treatment of gastric carcinoma is surgical resection However high incidence of loco regional failure warrants adjuvant treatment. Although the median overall survival is significantly better in patients who were treated with adjuvant chemoradiation however it is associated with changes in Quality of life (QOL) and toxicity, particularly hematologic and gastrointestinal. Material and Methods Thirty patients of gastric cancer who underwent curative resection were enrolled and received chemoradiotherapy Clinical: Upper GI PO-215 To evaluate the tolerance of adjuvant