AOAC SPIFAN Stakeholder Panel Meeting Book (September 7, 2019)
Major Human Milk Oligosaccharides
LNnH LSTa
LNH LNDFH-II
• • •
Complex mixture of oligosaccharides
LSTb LNFP-V
3'SL
LNFP-II LSTc
>200 HMO detected ~ 160 HMO identified
2'FL
LNnT
• Quantitative data available for ~30 HMO
6'SL
2.74-2.77 g/L
LDFT
Predominant HMO 1 •
FLNH-II
1.09-1.31 g/L
2’FL, LNFP-I, LNDFH-I
LNFP-I
• DSLNT, 6’SL, LST-c, LST-b, LST-a, 3’SL
LNFP-III
0.8-1.04 g/L
Chart: • Summary of data from ~13 articles (medians used) • Data from multiple stages of lactation
DFLNH-b
0.8 g/L
LNT
DSLNT
3FL
LNDFH-I
DFLNH-I
Chart received from S. Austin
1 Urashima et.al. (2011) Milk Oligosaccharides, Chapter III p. 27
Data on chart: Thurl et.al. (2017) Nutrition Reviews 75 : 920-933
Milk Groups
• Human milk can be assigned to one of 4 milk groups (similar to blood groups) • Groups depend on the activity of 2 enzymes, fucosyltransferase 2 ( FUT2 ) encoded by the secretor gene & fucosyltransferase 3 ( FUT3 ) encoded by the Lewis gene. • FUT2 is responsible for adding fucose to HMO via an Ş-1,2-linkage to terminal Gal. • FUT3 is responsible for adding fucose to HMO via an Ş-1,4-linkage to subterminal GlcNAc
D-G D-G
8 6
4
3
2
ɴ ɲ
N- L-F
Received from S. Austin
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