AOAC SPIFAN Stakeholder Panel Meeting Book (September 7, 2019)

The Indian Matrices Matrices under the SLV program • Child formula • Adult nutritional • Infant Milk Formula • Infant cereal-based product • Malt based health drink • Malt chocolate health drink

• SPIFAN Adult Nutritional Powder Low Fat (00859RF00)* • SPIFAN Infant Formula Powder Milk Based (K16NTAV)* • SPIFAN Infant Formula Powder Soy Based (E10NWZC)* *included based on comments of NUTRIENTS EXPERT REVIEW PANEL (ERP), March 14, 2019

SLV Protocol- Based on AOAC Guidelines for Single Laboratory Validation A. Linearity - 3-day triplicate recoveries at multiple calibration curve locations to average 95-105% B. LOD/LOQ – 5 independent days run the reagent blank (not microwave digested) as a sample. LOQ is the blank mean + 10 *SD. LOQ must be < SMPR criterion. C. Precision - Every matrix in duplicate (<5% RSD) on each day, 6 days, 2 analysts, over all intermediate precision <10% RSD. D. Accuracy - 100% spike (of its mean precision value in respective sample), on 6 days by 2 analysts. Spike recoveries must be 90 - 110%

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