CPB Ljubljana 2018 course book

Effect of chemotherapy

Cochrane metaanalysis

▪ 13 trials, 3128 patients ▪ Individual data ▪ OS : +6% at 5 y, HR = 0.81 ▪ Benefit for LC and meta ▪ Platinum or non platinum ▪ Mainly for stage I-II ▪ No effect of age, nodal status

Cisplatin weekly 40 mg/m2

Chemoradiotherapy for Cervical Cancer Meta- Analysis Collaboration, J Clin Oncol 2010