CPB Ljubljana 2018 course book

HDR- ICBT: late complications

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Clinical Data

HDR vs LDR

➢

Review literature * (Fu and Phillips 1990) Meta-analysis 17 068 pts (Orton 1991) Randomised Phase III (Patel 1994)

G2-4 12 % 18 %

➢

G3-4 2.2% 5.3% p<0.00

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G1-4 6.4% 19.9%

p<0.001

G3-4 0.4% 2.4% p> 0.05

* majority Fx 7.8 Gy to point A