IMRT

3D vs IMRT: LUNG

41 pts Stage IIIA-IIIB PTV: 623cc (75-1645) Upper location

V5: 52 vs 59 (ns) V10: 45 vs 38 (p<0.01) (IMRT benefit 7-10%) V20: 35 vs 25 (p<0.01) (IMRT benefit 7-10%) MLD 19 vs 17 Gy NTCP: 36 vs 9% (Burman);13 vs 7% (Hyman)

Murshed IJROBP 2004

Node - Node +

V20: 25.6 vs 23.6%

Grills IJROBP 2003

36.3 vs 23.6% ( IMRT benefit ≈ 15% )

MLD: 15.3 vs 15.4 Gy 21.5 vs 15.4 V5: 3D benefit 8% V10: IMRT benefit 1.6% V20: IMRT benefit 8% V30: IMRT benefit 8.9%

Stage I-IIIB 10 pts

Liu IJROBP 2004