IMRT

Phase II study 2005 – 2010

 108 patients with cT3-4 rectal cancer treated preoperatively

 Radiotherapy (RT): 23 x 2 Gy with IG-IMRT by helical tomotherapy with daily MVCT scan positioning and without concurrent chemotherapy

 SIB of 0.4 Gy/day on the primary tumor up to a total dose of 55.2 Gy for patients with a narrow CRM on MRI ( ≤ 2 mm) to maintain oncological safety

Radiotherapy

follow-up

Late toxicity Outcome

adjuvant chemotherapy

5-6 weeks

5 weeks

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