SPADA Book - April 11, 2017
Technical Assessment: Sequencing Working Group Discussion and analysis based on August 2016 National Academy of Sciences discussion regarding the potential for use of amplicon sequencing Focused on technical assessment of metagenomic and amplicon sequencing • Document and/or leverage existing sequencing activities across multiple agencies and laboratories • Assess strengths and weaknesses of approaches
Membership — Sequencing Experts • Federal agencies
• BioWatch laboratories • Other laboratory experts
Meetings or teleconferences on a monthly or bi-weekly basis
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Informing the Sequencing Working Group Development of Program Requirements • “Value to stakeholder” sequencing discussion with local laboratory directors/designees • Identify level of characterization required to inform public health decisions • Develop stakeholder questionnaire • Effectiveness criteria • Suitability criteria • Feedback generated will inform the Program requirement development and discussions of the Sequencing Working Group
Evaluate targeted amplicon sequencing as well as metagenomics
Identify opportunities to leverage clinical and non-clinical applications; areas of overlap as well as separation
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