Biophysical Society 60th Annual Meeting

1305-Pos Board B282 HUMAN INDUCED PLURIPOTENT STEM CELLS-DERIVED CARDIOMYO- CYTES CARRYING CALM1-F142L MUTATION RECAPITULATE LQTS PHENO- TYPE IN VITRO. Marcella Rocchetti , Luca Sala, Lisa Dreizehnter, Manuela Mura, Claudia Altomare, Joyce Bernardi, Carlotta Ronchi, Stefano Severi, Alfred L. George, Peter J. Schwartz, Daniel Sinnecker, Massimiliano Gnecchi, Lia Crotti, Alessandra Moretti, Antonio Zaza 1306-Pos Board B283 INTERNATIONAL TRAVEL AWARDEE LOCAL CHARACTER OF RELEASE-DEPENDENT INACTIVATION OF L-TYPE CALCIUM CURRENT. Barbora Hoffmannova , Eva Polakova, Alexandra jr. Zahradnikova, Alexandra Zahradnikova, Ivan Zahradnik 1307-Pos Board B284 SUPPRESSION OF CARDIAC ICA AND CA 2+ RELEASE BY ACUTE HYPOXIA AND ACIDIFICATION.  Jose Carlos Fernandez-Morales , Xiao Hua Zhang, Lars Cleemann, Martin Morad 1308-Pos Board B285 STIM-ORAI INTERACTION IN SCHISTOSOMA MANSONI INDICATES THE EXISTENCE OF FUNCTIONAL STORE-OPERATED CALCIUM ENTRY IN THE PARASITE. Ana Eliza Zeraik , Marina Gabriel Fontes, Jose Luiz Souza Lopes, Ana Paula Ulian Araujo, Ricardo DeMarco 1309-Pos Board B286 INHIBITOR OF STORE-OPERATED CALCIUM ENTRY YM58483 SHOWS SIMI- LAR PHARMACOLOGICAL PROFILE TO NON-STEROIDAL ANTI-INFLAMMA- TORY DRUG CELECOXIB. Alexandra S. Gherghina , Aurelien Boillat, Shihab Shah, Nikita Gamper 1310-Pos Board B287 ZINC INHIBITS ORAI1-MEDIATED CALCIUM SIGNALS IN ESOPHAGEAL CANCER CELLS. Sangyong Choi, Chaochu Cui, Yanhong Luo, Sun Hee Kim, Jae-Kyun Ko, Jianjie Ma, Irina Korichneva, Zui Pan 1311-Pos Board B288 ORAI1 CONCATEMERS REVEAL A HEXAMERIC ORAI1 CHANNEL ASSEM- BLY. Xiangyu Cai , Yandong Zhou, Xianming Wang, Natalia Loktionova, Robert Nwokonko, Mohamed Trebak, Donald Gill 1312-Pos Board B289 STIM1-INDUCED CLUSTERING OF ORAI1 CHANNELS. Robert Nwokonko , Yandong Zhou, Xiangyu Cai, Natalia Loktionova, Xianming Wang, Donald Gill 1313-Pos Board B290 ACTIVATION MECHANISM OF THE CALCIUM RELEASE-ACTIVATED CAL- CIUM CHANNEL REVEALED BY THE GATING COMPETENCE OF CONSTITU- TIVELY OPEN ORAI MUTANTS. Hao Dong 1314-Pos Board B291 MOLECULAR MECHANISMS OF STIM1-MEDIATED ORAI-1 CHANNEL ACTI- VATION. Zainab Haydari , Hengameh Shams, Mohammad R K Mofrad 1315-Pos Board B292 IMPACT OF STIM1 R304WMUTANT ON INTRA- AND INTERMOLECULAR CYTOSOLIC COILED-COIL INTERACTIONS. Marc Fahrner , Michael Stadlbauer, Martin Muik, Christoph Romanin Intracellular Calcium Channels and Calcium Sparks and Waves I (Boards B293 - B313) 1316-Pos Board B293 DIFFERENTIAL EFFECTS OF TEMPERATURE AND LIPIDS ON THE GAT- ING OF RYR AND SR K + CHANNELS. Sam El-Ajouz , Elisa Venturi, Rebecca Sitsapesan

1291-Pos Board B268 CPOW TRAVEL AWARDEE NEW TARGETED CA 2+ PROBES REVEAL MITOCHONDRIAL CA 2+ SIGNALING PLAYS A CRITICAL ROLE IN RAT SINOATRIAL (SA) NODAL PACING. Xiaohua Zhang , Christine Couch, Katalin Torok, Martin Morad 1292-Pos Board B269 PREVELEGED CA 2+ SIGNALING PATHWAY BETWEEN MEMBRANE NCX AND MITOCHONDRIA IN CARDIAC MYOCYTES. Xiaohua Zhang , Naohiro Yamaguchi, Lars Cleemann, Martin Morad 1293-Pos Board B270 BINDING SITES OF THE CA/NA EXCHANGER NCX ANALYZED WITH POIS- SON FERMI THEORY. Jinn-Liang Liu, Robert S. Eisenberg 1294-Pos Board B271 NEURONAL INTRACELLULAR CA 2+ AND NA + DYSHOMEOSTASIS IN THE MDX MOUSE.  Jose R. Lopez , Juan Kolster, Jose Adams 1295-Pos Board B272 ROLE OF INORGANIC POLYPHOSPHATE (POLYP) IN PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL RESPONSE TO GLUTAMATE IN MAMMALIAN NEURONS. Plamena R. Angelova , Andrey Y. Abramov 1296-Pos Board B273 CORTEX PHELLODENDRI EXTRACT RELAXES MOUSE AIRWAY SMOOTH MUSCLE. Weiwei Chen, Qui-Ju Jiang, Meng-Fei Yu, Qing-Hua Liu 1297-Pos Board B274 R-CEPIA1ER AS A NEW TOOL TO DIRECTLY MEASURE [CA] IN THE SARCO- PLASMIC RETICULUM OF VENTRICULAR MYOCYTES. Elisa Bovo , Aleksey V. Zima, Jody L. Martin, Pieter P. de Tombe 1298-Pos Board B275 SIMULATIONS OF SUBCELLULAR HETEROGENEITY IN CALCIUM BLINK KINETICS. Elisa Nunez Acosta , Eva Polakova, Eric A. Sobie 1299-Pos Board B276 DYADIC REMODELING AS A CAUSE OF IMPAIRED E-C COUPLING IN EARLY STAGES OF MYOCARDIAL INJURY. Alexandra jr. Zahradnikova , Marta Novotova, Katarina Mackova, Ivan Zahradnik, Alexandra Zahradnikova 1300-Pos Board B277 VENTRICULAR NA + -HCO3- COTRANSPORTER ACTIVITY AND INTRACEL- LULAR H + MOBILITY ARE REMODELED IN CARDIAC HYPERTROPHY AND HEART FAILURE. Kerrie L. Ford , Carolina D. Garciarena, Yanwen Wang, Yatong Li, Michael Lawless, Ming Lei, Andrew Trafford, Pawel Swietach, Richard D. Vaughan-Jones 1301-Pos Board B278 INTRACELLULAR CD38 MEDIATES CARDIAC SYNTHESIS OF NAADP AND CADPR. Wee Khang Lin , Emma Bolton, Matylda Maciejewska, Yanwen Wang, Wilian Cortopassi, Fiona O’Brien, Margarida Ruas, Ming Lei, Rebecca Sitsapesan, Antony Galione, Derek Terrar 1302-Pos Board B279 THE ROLE OF MITOPHAGY IN CARDIOMYOCYTE ARRHYTHMOGEN- ESIS. Kevin R. Murphy , Yichun Lu, Dmitry Terentyev, Gideon Koren 1303-Pos Board B280 ELECTRON-CONFORMATIONAL TRANSFORMATIONS GOVERN THE TEMPERATURE DEPENDENCE OF THE RYR2 GATING. Bogdan Iaparov , Alexander Moskvin, Alexander Ryvkin, Olga Solovyova 1304-Pos Board B281 CORRELATION OF MOLECULAR DYNAMICS ANALYSIS AND CALCIUM SIG- NALING IN MUTANT RYANODINE RECEPTORS. Toshiko Yamazawa , Takashi Murayama, Hideto Oyamada, Junji Suzuki, Nagomi Kurebayashi, Kazunori Kanemaru, Maki Yamaguchi, Chikara Sato, Masamitsu Iino

M O N D A Y

77