Biophysical Society 60th Annual Meeting

1329-Pos Board B306 STRUCTURAL DYNAMICS OF CALMODULIN IN REGULATION OF CARDIAC CALCIUM RELEASE IN HEALTH AND DISEASE. Megan R. McCarthy , Robyn T. Rebbeck, Razvan L. Cornea, David D. Thomas 1330-Pos Board B307 CARDIAC RYANODINE RECEPTOR CHANNEL GATING IS MODIFIED DURING BLOCKER-INDUCED CHANGES IN ION PERMEATION. Saptarshi Mukherjee , Nia L. Thomas, Alan J. Williams 1331-Pos Board B308 FRET-BASED MAPPING OF CALMODULIN WITHIN THE RYANODINE RECEP- TOR. Robyn T. Rebbeck , Bengt Svensson, Florentin R. Nitu, Montserrat Samso, Donald M. Bers, David D. Thomas, Razvan L. Cornea 1332-Pos Board B309 CALMODULIN REGULATION OF RYANODINE RECEPTORS (RYR2) DIFFERS IN FAILING AND NON-FALING HUMAN HEARTS DUE TO DIFFERENCES IN RYR2 PHOSPHORYLATION. Derek R. Laver , Kafa Walweel, Ye Win Oo, Dirk van Helden, Cris dos Remedios, Peter Molenaar 1333-Pos Board B310 PROTEIN PHOSPHATASE-1 INCREASES CALCIUM SPARK FREQUENCY IN MURINE CARDIOMYOCYTES VIA MODULATION OF RYR2 PHOSPHORYLA- TION. Duilio Michele Potenza , Miguel Fernandez-Tenorio, Ernst Niggli 1334-Pos Board B311 ABLATION OF TWO MAJOR PHOSPHORYLATION SITES IN RYR2 ALTER SARCOPLAMIC RETICULUM CALCIUM HANDLING AND INCREASES THE PROPENSITY TO ATRIAL FIBRILLATION. Roberto Ramos Mondragon , Em- manuel M. Camors, Yangyang Bao, Cicero B. Willis, Carmen Valdivia, Lori Isom, Jose Jalife, Hector H. Valdivia 1335-Pos Board B312 NITROSYLATION OF RYR2 PREVENTS ACTIVATION OF CA WAVES INDUCED BY REDOX-MEDIATED INTERSUBUNIT CROSS-LINKING. Elisa Bovo, Stefan R. Mazurek, Jody L. Martin, Pieter P. de Tombe, Aleksey V. Zima 1336-Pos Board B313 ZINC MODULATES SKELETAL RYANODINE RECEPTOR FUNCTION RESULT- ING IN ALTERED SARCOPLASMIC RETICULUM CALCIUM RELEASE. Gavin B. Robertson , Benedict Reilly-O’Donnell, Craig Balmforth, Samantha J. Pitt Cardiac Smooth and Skeletal Muscle Electrophysiology I (Boards B314 - B335) 1337-Pos Board B314 ELECTROPHYSIOLOGICAL PROPERTIES OF HUMAN INDUCED PLURIPO- TENT STEM CELL-DERIVED CARDIOMYOCYTES CULTURED ON A FLEXIBLE MATRIGEL SUBSTRATE. Lili Wang , Tromondae K. Feaster, Dmytro O. Kryshtal, Charles C. Hong, Bjorn C. Knollmann 1338-Pos Board B315 VARIABILITY OF THE FIELD POTENTIAL DURATION OF STEM CELL-DERIVED CARDIOMYOCYTES IS A PROARRHYTHMIC INDICATOR. Andrew Bruening- Wright , Carlos A. Obejero-Paz, James Kramer, Arthur M. Brown 1339-Pos Board B316 IMPEDANCE AND COMBINED EXTRACELLULAR FIELD POTENTIAL RECORDINGS OF CIPA REFERENCE COMPOUNDS ON IPS CARDIOMYO- CYTES. Corina Bot , Sonja Stoelzle-Feix, Nadine Becker, Krisztina Juhasz, Ulrich Thomas, Leo Doerr, Rodolfo Haedo, Matthias Beckler, Joerg Oest- reich, Michael George, Andrea Brüggemann, Niels Fertig 1340-Pos Board B317 EDUCATION TRAVEL AWARDEE MODELING ELECTROPHYSIOLOGICAL INTERACTIONS BETWEEN MES- ENCHYMAL STEM CELLS AND CARDIOMYOCYTES FOR IMPROVED CELL DELIVERY CARDIOTHERAPEUTICS.  Joshua Mayourian , Ruben M. Savizky, Eric A. Sobie, Kevin D. Costa

1317-Pos Board B294 DAMPENED ACTIVITY OF SINGLE RYANODINE RECEPTOR CHANNELS IN MICE DEVOID OF TRIC-A. Katja Witschas , Fiona O’Brien, Elisa Venturi, Sam El-Ajouz, Matthew Beech, David Eberhardt, Tsunaki Iida, Miyuki Nishi, Hiroshi Takeshima, Rebecca Sitsapesan 1318-Pos Board B295 SIMVASTATIN ACTIVATES SINGLE SKELETAL RYR1 CHANNELS BUT EXERTS MORE COMPLEX REGULATION OF THE CARDIAC ISOFORM, RYR2. Elisa Venturi , Katja Witschas, Sabine J. Lotteau, Emma Steer, Derek S. Steele, Sarah C. Calaghan, Rebecca Sitsapesan 1319-Pos Board B296 CPOW TRAVEL AWARDEE SIMVASTATIN HAS PROFOUND EFFECTS ON SARCOPLASMIC RETICULUM CA 2+ LEAK IN SKELETAL BUT NOT CARDIAC MUSCLE: A MECHANISM FOR MYOPATHY. Sabine Lotteau , Zhaokang Yang, Elisa Venturi, Emma Steer, Katja Witschas, Rebecca Sitsapesan, Derek Steele, Sarah Calaghan 1320-Pos Board B297 AXIAL MEMBRANE TUBULES IN ATRIAL CARDIOMYOCYTES CONFINE UL- TRARAPID INTRACELLULAR CALCIUM SIGNALS THROUGH A NEW SUPER- HUB MECHANISM. Sören Brandenburg, Tobias Kohl, George S.B. Williams, Konstantin Gusev, Eva Wagner, Elke Hebisch, Christopher W. Ward, W. J. Lederer, Stephan E. Lehnart 1321-Pos Board B298 CARDIAC PACEMAKER CELL FUNCTION AT A SUPER-RESOLUTION SCALE OF SIM: DISTRIBUTION OF RYRS, CALCIUM DYNAMICS, AND NUMERI- CAL MODELING. Victor A. Maltsev , Alexander V. Maltsev, Magdalena Juhaszova, Syevda Sirenko, Oliver Monfredi, Hari Shroff, Andrew York, Steven J. Sollott, Edward G. Lakatta, Michael D. Stern 1322-Pos Board B299 RELATIVE CONTRIBUTION OF LOCAL CA 2+ RELEASES (LCRS) AND AP-IN- DUCED CA 2+ TRANSIENT DECAY TO DIASTOLIC DEPOLARIZATION IN RAB- BIT SA NODE CELLS. Oliver J. Monfredi , Alexander Maltsev, Sean Parsons, Bruce Ziman, Edward Lakatta, Michael D. Stern, Victor A. Maltsev 1323-Pos Board B300 ENHANCED RYR2 CHANNEL ACTIVITY BUT REDUCED CA 2+ SPARK OC- CURRENCE IN FAILING MICE CARDIOMYOCYTES. Linwei Li , Gema Ruiz- Hurtado, Maria Fernandez-Velasco, Angelica Rueda, Florence Lefebvre, Yue Yi Wang, Philippe Mateo, Cecile Cassan, Barnabas Gellen, Jean Pierre Benitah, Ana M. Gomez 1324-Pos Board B301 CHARACTERIZATION OF CA 2+ -INDUCED CA 2+ RELEASE VIA RYR2 CARRYING ARRHYTHMOGENIC MUTATIONS. Nagomi Kurebayashi , Takashi Murayama, Junji Suzuki, Kazunori Kanemaru, Masamitsu Iino, Takashi Sakurai 1325-Pos Board B302 INHIBITION OF RYR2 ACTIVITY BY INTRACELLULAR FLECAINIDE EFFECTIVE- LY SUPPRESSES ARRHYTHMOGENIC CA WAVES IN INTACT VENTRICULAR MYOCYTES FROM CASQ2 -/- MICE. Dmytro Kryshtal , Björn C. Knollmann 1326-Pos Board B303 MANIPULATION OF RYANODINE RECEPTOR ACTIVITY MODULATES AUTO- IMMUNE RESPONSES IN MICE. Natalia C. Osipchuk, Paul D. Allen, Lillian Cruz-Orengo, Athena Soulika, Alla Fomina 1327-Pos Board B304 HIGH-THROUGHPUT SCREENS TO DISCOVER INHIBITORS OF LEAKY RY- ANODINE RECEPTOR CALCIUM CHANNELS. Robyn T. Rebbeck, Florentin R. Nitu, David D. Thomas, Donald M. Bers, Razvan L. Cornea 1328-Pos Board B305 FLUORESCENCE-LABELED IMPERACALCIN BINDS TO OPEN RYR2 CHAN- NELS IN MOUSE VENTRICULAR MYOCYTES. Liang Xiao , Yi Yang, Geogina B. Gurrola, Florentin R. Nitu, José Luis Puglisi, Liming Zhang, Razvan L. Cornea, Donald M. Bers, Héctor H. Valdivia

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