Biophysical Society 60th Annual Meeting

1420-Pos Board B397 FUNCTIONAL ROLES OF A CONSERVED TRYPTOPHAN AT SUBUNIT-SUB- UNIT INTERFACES IN NMDA RECEPTOR MEMBRANE REGIONS. Madeleine R. Wilcox , Nathan G. Glasgow, Jon W. Johnson 1421-Pos Board B398 INTRA AND INTERDOMAIN MOTIONS OF THE NMDA RECEPTOR USING SINGLE MOLECULE FRET. Drew Dolino , Sudeshna Chatterjee, David Cooper, Henriette Jaurich, Swarna Ramaswamy, Soheila Rezaei Adariani, Hugo Sanabria, Christy Landes, Vasanthi Jayaraman 1422-Pos Board B399 MPX-004: A NEW PHARMACOLOGICAL TOOL TO STUDY THE PHYSIOLOGY OF NMDA RECEPTORS CONTAINING THE GLUN2A SUBUNIT. Robert A. Volkmann, Christopher Fanger , David R. Anderson, Frank S. Menniti 1423-Pos Board B400 STRUCTURAL AND FUNCTIONAL COUPLING BETWEEN BK CHANNELS AND NMDA RECEPTORS.  Jiyuan Zhang , Qin Li, Xin Guan, Hui-Lin Pan, Jiusheng Yan 1424-Pos Board B401 LOCAL CA 2+ NANODOMAINS INITIATE CA 2+ /CALMODULIN-DEPENDENT INACTIVATION OF NMDA RECEPTORS. Gary Iacobucci 1425-Pos Board B402 MODULATION OF GLUTAMATE RECEPTORS BY AUXILIARY PROTEINS A STRUCTURAL INVESTIGATION. Douglas B. Litwin , Garam Lee, David Maclean, Vasanthi Jayaraman 1426-Pos Board B403 FUNCTIONAL AND STRUCTURAL CHARACTERIZATION OF THE GLUK2/ GLUK5 HETEROTETRAMER GATING MECHANISM. Teresa Paramo , Patricia M.G.E. Brown, Mark R. P. Aurousseau, Maria Musgaard, Derek Bowie, Philip C. Biggin 1427-Pos Board B404 CONFORMATIONAL DYNAMICS OF THE GLUK2 LIGAND-BINDING DO- MAIN. Tyler J. Wied , Albert Y. Lau 1428-Pos Board B405 CID TRAVEL AWARDEE IDENTIFICATION OF FUNCTIONAL DETERMINANTS OF KAINATE RECEP- TOR MODULATION BY AUXILIARY PROTEIN NETO2. Theanne N. Griffith , Geoffrey T. Swanson 1429-Pos Board B406 MECHANISMS OF GLUTAMATE CAPTURE BY A CLAMSHELL BINDING DO- MAIN. Alvin Yu , Héctor Salazar, Andrew J. R. Plested, Albert Y. Lau 1430-Pos Board B407 COMPUTATIONAL STUDY OF THE IMPACT OF THE L483Y MUTATION ON THE DESENSITIZATION OF THE AMPA RECEPTOR. Rémi Cuchillo , Philip C. Biggin 1431-Pos Board B408 STRUCTURAL EFFECTS OF PHOSPHORYLATION ON C-TERMINAL SEGMENT OF AMPA RECEPTOR. Caitlin E. Nurik , Sudeshna Chattergee, Suma Devi, David R. Cooper, Swarna S. Ramaswamy, Christy Landes, James Howe, Vasanthi Jayaraman 1432-Pos Board B409 ACTIVATING INDIVIDUAL SUBUNITS OF TMEM16A CALCIUM-ACTIVATED CHLORIDE CHANNELS. Grace Jeng, Muskaan Aggarwal, Wei-Ping Yu, Tsung-Yu Chen 1433-Pos Board B410 MOLECULAR MECHANISMS OF PERMEATION IN TMEM16B CA 2+ -ACTIVAT- ED CL¯ CHANNEL. Simone Pifferi

1434-Pos Board B411 SIZING UP THE LIPID PATHWAY IN A TMEM16 PHOSPHOLIPID SCRAMBLA- SE. Mattia Malvezzi , Rabia Iqbal, Ashley Brown, Anant Menon, Alessio Accardi 1435-Pos Board B412 STRUCTURES OF THE MG 2+ CHANNEL CORA IN THE OPEN STATE BY CRYO ELECTRON MICROSCOPY. Doreen Matthies, Olivier Dalmas, Mario Bor- gnia, Pawel Dominik, Alan Merk, Prashant Rao, Bharat Reddy, Shahidul Islam, Alberto Bartesaghi, Eduardo Perozo , Sriram Subramaniam 1436-Pos Board B413 CRYSTAL STRUCTURE AND ASYMMETRIC CONFORMATION OF A K + CHANNEL RCK DOMAIN. Victor P. Pau, Karin Abarca-Heidemann, Eunan Hendron, Marc Stezzi, Gino Cingolani, Brad S. Rothberg 1437-Pos Board B414 CONFORMATIONAL DYNAMICS OF THE CLOSED STATE OF KCSA IN LIPID BICELLES. Dorothy M. Kim , Igor Dikiy, Vikrant Upadhyay, David Posson, David Eliezer, Crina Nimigean 1438-Pos Board B415 REGULATION OF CNGA1 CHANNEL GATING BY INTERACTIONS WITH THE MEMBRANE. Teresa K. Aman , Sharona E. Gordon, William N. Zagotta 1439-Pos Board B416 DOES BIMODAL AGONISM IN CYCLIC NUCLEOTIDE-GATED (CNG) CHANNELS PRESERVE THE CLASSICAL BINDING SITE AND PORE STRUC- TURE? Robynn Lester, Edgar C. Young Cardiac Muscle Mechanics and Structure I (Boards B417 - B444) 1440-Pos Board B417 DEVELOPMENT OF HIGH AFFINITY ANTI-S2 PEPTIDES FOR STABILIZING THE MYOSIN COILED COIL. Negar Aboonasrshiraz, Ashley Huang, Cynthia Y. Ma, Douglas D. Root 1441-Pos Board B418 COMPETITIVE BINDING TO MYOSIN S2 BY C-PROTEIN, ANTI-S2 PEPTIDES, AND ANTIBODIES MODULATE MYOSIN COILED COIL STABILITY AND MYOFIBRIL CONTRACTILITY. Rohit Singh , Veronica J. Zheng, Cynthia Y. Ma, Douglas D. Root 1442-Pos Board B419 THE N-TERMINAL DOMAINS OF MYBPC3 RESTRICT ACTIN DYNAMICS AND INCREASE RESILIENCE IN A PHOSPHORYLATION-DEPENDENT MAN- NER. Brett A. Colson, Alfred Gallegos , Brian Lin, Sakthivel Sadayappan, David D. Thomas 1443-Pos Board B420 PHOSPHORYLATION AND CALCIUM ANTAGONISTICALLY TUNE MYOSIN- BINDING PROTEIN C’S MOLECULAR STRUCTURE AND FUNCTION. Michael J. Previs , Ji Young Mun, Arthur J. Michalek, Samantha Beck Previs, James Gulick, Jeffrey Robbins, David M. Warshaw, Roger Craig 1444-Pos Board B421 STRUCTURAL MEASUREMENTS WITHIN THE M-DOMAIN REVEAL UNIQUE DETAILS OF CARDIAC MYOSIN BINDING PROTEIN-C PHOSPHORYLA- TION. Brett A. Colson , L. Michel Espinoza-Fonseca, David D. Thomas 1445-Pos Board B422 REGULATION OF THE SUPER-RELAXED STATE OF MYOSIN BY CARDIAC MYOSIN BINDING PROTEIN-C.  James W. McNamara , Amy Li, Sean Lal, Johan M. Bos, Michael J. Ackerman, Cristobal G. dos Remedios, Samantha P. Harris, Roger Cooke

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