Biophysical Society 60th Annual Meeting

Symposium Optogenetics in Neuroscience 4:00 pm - 6:00 pm, Petree Hall C

1806-Plat 4:30 pm UNDERSTANDING VISCOELASTICITY CHANGES IN SINGLE CELLS USING VARIABLE INDENTATION-RATE VISCOELASTIC ANALYSIS. Matthew A. Caporizzo , Patrick Robison, Alexey Bogush, Benjamin L. Prosser, David M. Eckmann, Russell J. Composto 1807-Plat 4:45 pm CELLULAR STRESS AFFECTS THE NUCLEOSKELETON IN DILATED CARDIO- MYOPATHY. Marlene Pluess, Thomas Iskratsch, Pauline Bennett, Joseph Dwyer, Pragati Pandey, Cristobal dos Remedios, Elisabeth Ehler 1808-Plat 5:00 pm SIMULTANEOUS HIGH-PRECISION IMAGING OF LOCAL CALCIUM AND SINGLE SARCOMERE LENGTH IN RAT NEONATAL CARDIOMYOCYTES VIA EXPRESSION OF YELLOW CAMELEON-NANO140 IN Z-DISCS.  Seiichi Tsukamoto, Kotaro Oyama , Teruyuki Fujii, Fuyu Kobirumaki-Shimozawa, Togo Shimozawa, Seine A. Shintani, Shin’ichi Ishiwata, Norio Fukuda 1809-Plat 5:15 pm ELECTRON TOMOGRAPHY OF MITOCHONDRIAL NANOTUNNELS IN A CPVT MODEL WITH RYR2 LOSS-OF-FUNCTION MUTATION. Manuela Lavorato , V.Ramesh Iyer, Yang-Ting Zhao, Hector Valdivia, Clara Franzini- 5:30 pm CORRELATING STRUCTURE AND FUNCTION IN HUMAN GENETIC VARI- ANTS OF PHOSPHOLAMBAN AND SARCOLIPIN.  Joseph O. Primeau, Gareth P. Armanious, Jessica L. Gifford, Catharine A. Trieber, Howard S. Young 1811-Plat 5:45 pm THE N-TERMINI OF SARCOLIPIN AND PHOSPHOLAMBAN PLAY AN IM- PORTANT ROLE IN DISTINCT REGULATION OF SARCO-ENDOPLASMIC RE- TICULUM CA 2+ ATPASE (SERCA) FUNCTION.  Sanjayaka K. Sahoo , Sana A. Shaikh, Danesh H. Sopariwala, Naresh C. Bal, Dennis S. Bruhn, Wojciech Kopec, Himanshu Khandelia, Muthu Periasamy Platform Protein Stability, Folding, and Chaperones II 4:00 pm - 6:00 pm, Room 502B Co-Chairs STRUCTURE AND STABILITY OF HSP60 AND GROEL IN SOLUTION.  Caterina Ricci , Giampaolo Barone, Donatella Bulone, Giosalba Burgio, Rita Carrotta, Fabio Librizzi, Antonella Marino Gammazza, Maria Rosalia Mangione, Antonio Palumbo Piccionello, Pier Luigi San Biagio, Angelo Spinello, Francesco Spinozzi, Silvia Vilasi, Maria Grazia Ortore 1814-Plat 4:30 pm QUANTIFICATION OF MACROMOLECULAR CROWDING IN LIVING CELLS.  Arnold Boersma , Boqun Liu, Christoffer Aberg, Bert Poolman 1815-Plat 4:45 pm INSIGHTS FROM THE FIRST PRINCIPLES BASED LARGE SCALE PROTEIN THERMOSTABILITY CALCULATIONS.  Vytautas Gapsys , Servaas Michielssens, Daniel Seeliger, Bert L. de Groot 1816-Plat 5:00 pm HIGHLY CHARGED PROTEINS ARE THE ACHILLES’ HEEL OF AGING PRO- TEOMES.  AdamM. R. de Graff , Michael J. Hazoglou, Ken A. Dill Armstrong 1810-Plat Logan Ahlstrom, University of Michigan Patrick Wintrode, University of Maryland 1812-Plat 4:00 pm OVERCOMING HETEROGENEITY TO STUDY THE STRUCTURE AND AS- SEMBLY OF SMALL HEAT-SHOCK PROTEIN CHAPERONES WITH NON- AGGREGATING CLIENTS. Miranda Collier , Justin Benesch 1813-Plat 4:15 pm INTERNATIONAL TRAVEL AWARDEE

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Chair Edward S. Boyden, MIT 1796-Symp

4:00 pm TOOLS FOR ANALYZING AND REPAIRING COMPLEX BIOLOGICAL SYSTEMS. Edward Boyden 1797-Symp 4:30 pm CONTROLLING BIOLOGICAL PATHWAYS WITH PHOTOPHARMACOLOGY.  Dirk Trauner 1798-Symp 5:00 pm TOOLS FOR ANATOMICAL AND FUNCTIONAL ANALYSIS OF WIDELY DIS- TRIBUTED BRAIN NETWORKS.  Viviana Gradinaru 1799-Symp 5:30 pm NATURAL ANION CHANNEL RHODOPSINS: A NEW FAMILY OF TOOLS FOR OPTOGENETIC NEURAL INHIBITION.  John L. Spudich Symposium p-ATPases: Structure, Mechanism, and Disease 4:00 pm - 6:00 pm, Petree Hall D Chair David Gadsby, Rockefeller University 1800-Symp 4:00 pm HYBRID FUNCTION OF THE NA/K-ATPASE: PROTON IMPORT ACCOMPA- NYING NA/K EXCHANGE.  David Gadsby , Natascia Vedovato 1801-Symp 4:30 pm SNAPSHOTS OF P-TYPE ATPASES - FROM CRYSTAL STRUCTURES TO SINGLE-MOLECULE STUDIES.  Poul Nissen 1802-Symp 5:00 pm THE NEW KIDS IN THE BLOCK: FE 2+ TRANSPORT P-ATPASES.  José M. Argüello 1803-Symp 5:30 pm SECRETORY PATHWAY CALCIUM ATPASES IN BREAST CANCER.  Rajini Rao , Donna Dang, José P. Llongueras Platform Cardiac Muscle Mechanics and Structure 4:00 pm - 6:00 pm, Room 502A Co-Chairs Clara Franzini-Armstrong, University of Pennsylvania Howard Young, University of Alberta, Canada 1804-Plat 4:00 pm FUNCTIONAL IMBALANCE AMONG INDIVIDUAL CARDIOMYOCYTES CAUSED BY CELL-TO-CELL VARIATION IN MUTANT MRNA EXPRESSION. A POSSIBLE TRIGGER FOR HYPERTROPHIC CARDIOMYOPATHY.  Theresia Kraft, Mirza Makul, Julia Beck, Judith Montag, Ante Radocaj, Andreas Perrot, Antonio Francino, Francesc Navarro-Lopéz, Cristobal G. dos Remedios, Bernhard Brenner 1805-Plat 4:15 pm DIFFERENTIAL EFFECTS OF CAMKII ACTIVITY IN HCM-LINKED TNT MUTA- TIONS.  Sarah J. Lehman , Lauren Tal-Grinspan, Melissa Lynn, Mark E. Anderson, Jil C. Tardiff

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