Biophysical Society 60th Annual Meeting

Intracellular Calcium Channels and Calcium Sparks and Waves II (Boards B286 - B304) 2142-Pos Board B286 SHG-2PF IMAGING OF LOCAL CA 2+ AND SUB-SARCOMERE CONTRACTION IN LIVE CARDIOMYOCYTES. Samir Awasti, Leighton T. Izu , Ziliang Mao, Zhong Jian, Ye Chen-Izu, James W. Chan 2143-Pos Board B287 ONE AND TWO-PHOTON CALCIUM UNCAGING WITH VISIBLE LIGHT IN CARDIAC MYOCYTES. Radoslav Janicek , Hitesh K. Agarwal, Graham C.R. Ellis-Davies, Ernst Niggli 2144-Pos Board B288 MOLECULAR ASSEMBLY OF THE MITOCHONDRIAL CALCIUM UNIPORTER COMPLEX. Ming-Feng Tsai , Christopher Miller 2145-Pos Board B289 MITOCHONDRIAL PERMEABILITY TRANSITION PORE OPENING PRO- MOTES CALCIUM ALTERNANS AND WAVES IN VENTRICULAR MYO- CYTES. Zhen Song , Richard Gordan, James N. Weiss, Lai-Hua Xie, Zhilin Qu 2146-Pos Board B290 MITOCHONDRIAL SK CHANNELS ATTENUATE CA-DEPENDENT ARRHYTH- MIA IN HYPERTROPHIC HEARTS BY REGULATING MITO-ROS-DEPENDENT OXIDATION AND ACTIVITY OF RYR. TaeYun Kim, Weiyan Li, Radmila Terentyeva, Karim Roder, Man Liu, Ian Greener, Richard T. Clements, Samuel C. Dudley, Gideon Koren, Bum-Rak Choi, Dmitry Terentyev 2147-Pos Board B291 DIASTOLIC CALCIUM LEAK AND THE ROLE OF ZINC. Benedict Reilly- O’Donnell , Gavin B. Robertson, Angela Karumbi, Alan J. Stewart, Samantha J. Pitt 2148-Pos Board B292 ASSOCIATION BETWEEN β3-ADRENOCEPTOR ACTIVATION AND INTRA- CELLULAR FREE ZINC ION INCREASE CONTRIBUTES TO HYPERGLYCEMIA- INDUCED CARDIAC ER-STRESS. Erkan Tuncay, Aysegul Toy, Belma Turan 2149-Pos Board B293 SHEAR STRESS ENHANCES CA 2+ SPARK OCCURRENCE IN RAT VENTRICU- LAR MYOCYTES VIA MITOCHONDRIAL NADPH OXIDASE-REACTIVE OXY- GEN SPECIES SIGNALING.  Jun Wang , Joon-Chul Kim, Sun-Hee Woo 2150-Pos Board B294 X-ROS SIGNALING IN ATRIAL MYOCYTES PRODUCES ARRHYTHMOGENIC CA 2+ WAVES. Maura Greiser , Ramzi J. Khairallah, Chris Ward, W. Jonathan Lederer 2151-Pos Board B295 NOVEL INSIGHTS INTO SINOATRIAL NODAL CELL LOCAL CALCIUM RELEAS- ES (LCRS) FROM AUTOMATED COMPUTER ANALYSIS IN SPONTANEOUSLY BEATING CELLS. Alexander V. Maltsev , Sean Parsons, Edward G. Lakatta, Michael D. Stern, Victor A. Maltsev, Oliver J. Monfredi 2152-Pos Board B296 SYNCHRONIZATION OF LOCAL CALCIUM RELEASES (LCRS) IN GUINEA PIG SINGLE, ISOLATED SA NODE CELLS CONTRIBUTES TO GENERATION OF RHYTHMIC ACTION POTENTIAL-INDUCED CA 2+ TRANSIENTS. Mary S. Kim , Larissa A. Maltseva, Alexander V. Maltsev, Sean P. Parsons, Oliver Monfredi, Kenta Tsutsui, Syevda Sirenko, Bruce Ziman, Edward G. Lakatta, Victor A. Maltsev 2153-Pos Board B297 COMPUTATIONAL ANALYSIS OF HEART-FAILURE-RELATED REMODEL- ING OF CYTOSOLIC AND NUCLEAR CALCIUM HANDLING IN THE CANINE ATRIAL CARDIOMYOCYTE.  Jordi Heijman , Xiao Yan Qi, Dobromir Dobrev, Stanley Nattel

2129-Pos Board B273 SINGLE VESICLE RECORDING IN HIPPOCAMPAL ‘XENAPSES’ REVEALS DIFFUSIONAL DISPERSION OF SV PROTEINS AFTER FUSION.  Julia Trahe , Ulrike Keller, Yaroslav Tsytsyura, Carsten Reissner, Jacob Piehler, Markus Missler, Jurgen Klingauf 2130-Pos Board B274 FUSION BETWEEN V-SNARE NANODISCS AND “FLIPPED” T-SNARE CELLS: CONTROL OF FUSION PORE NUCLEATION AND LIFETIMES BY SNARE PRO- TEIN TRANSMEMBRANE DOMAINS. Zhenyong Wu, Sarah Marie Auclair, Oscar Daniel Bello, Wensi Vennekate, Natasha Dudzinski, Shyam Sundar Krishnakumar, Erdem Karatekin 2131-Pos Board B275 PHYSIOLOGICAL IMPLICATIONS OF SLOW FUSION PORE EXPANSION ON PROTEIN DISCHARGE: LIKELY INHIBITION OF TISSUE PLASMINOGEN AC- TIVATOR BY ITS CO-PACKAGED PROTEIN INHIBITOR. Kevin P. Bohannon , Mary A. Bittner, Daniel Axelrod, Ronald W. Holz 2132-Pos Board B276 MUNC18-1-REGULATED STAGE-WISE SNARE ASSEMBLY UNDERLYING SYNAPTIC EXOCYTOSIS. Yongli Zhang 2133-Pos Board B277 EFFECT OF TWO DISEASE-CAUSING MUTATIONS ON THE ENERGETICS AND KINETICS OF SNARE ASSEMBLY. Aleksander A. Rebane , Shyam Krishnakumar, James E. Rothman, Yongli Zhang 2134-Pos Board B278 ROLES OF VAMP7 IN DROSOPHILA SYNAPTIC TRANSMISSION.  Ismael D. Santiago , Bryan Meléndez, J. Troy Littleton, Ramon Jorquera 2135-Pos Board B279 SYNAPSIN NULL INCREASES CALCIUM SENSITIVITY OF VESICLE FU- SION AND ALTER SHORT-TERM SYNAPTIC MEMORY AT DROSOPHILA NMJ. Agustin Gonzalez Ruiz , Ramon A. Jorquera 2136-Pos Board B280 MATHEMATICAL MODELING SUPPORTS THE HYPOTHESIS THAT SYNAP- TOTAGMIN RINGS CLAMP FUSION.  Jie Zhu , Ben O’Shaughnessy, James Board B281 MOLECULAR DYNAMICS SIMULATIONS OF SYNAPTOTAGMIN BINDING TO LIPID BILAYERS. Maria Bykhovskaia 2138-Pos Board B282 SYNAPTOTAGMIN-1 BINDS TO PIP2-CONTAINING MEMBRANE BUT NOT TO SNARES AT PHYSIOLOGICAL IONIC STRENGTH. Yongsoo Park 2139-Pos Board B283 INVERSION OF LIGAND BINDING PREFERENCES IN RE-ENGINEERED DYS- FERLIN C2AV1. Faraz Harsini , Anne Rice, Kerry Fuson, R. Bryan Sutton 2140-Pos Board B284 MULTIVALENT MEMBRANE LIPID TARGETING BY THE CALCIUM-INDEPEN- DENT C2 DOMAINS OF GRANUPHILIN: EVIDENCE FROM COMPUTATION AND EXPERIMENT. Abena Watson-Siriboe, Jack Henderson, J. Ryan Osterberg, Daniel T. Giardina, Marissa DeLima, Hai Lin, Jefferson Knight 2141-Pos Board B285 IS BURSTING MORE EFFECTIVE THAN SPIKING IN EVOKING PITUITARY HORMONE SECRETION? A SPATIOTEMPORAL SIMULATION STUDY OF CALCIUM DIFFUSION AND EXOCYTOSIS. Alessia Tagliavini , Joel Tabak, Richard Bertram, Morten G. Pedersen Rothman 2137-Pos

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