Biophysical Society 60th Annual Meeting

2216-Pos Board B360 MOLECULAR DYNAMICS SIMULATIONS OF MUTANT K CHANNELS IN- VOLVED IN SEVERE EARLY ONSET EPILEPSY. Robert A. Farley , Yi Shi, Yibo Wang, Van Ngo, Sergei Noskov 2217-Pos Board B361 A MISSENSE MUTATION IN THE SELECTIVITY FILTER OF BK AFFECTS THE CHANNEL’S POTASSIUM CONDUCTANCE.  João L. Carvalho-de-Souza , Tomoya Kubota, Xiaofei Du, Ramon Latorre, Christopher M. Gomez, Francisco Bezanilla 2218-Pos Board B362 PHARMACOLOGY AND REGULATION OF FUNGAL K2P CHANNELS. Ryan W. Manville , Fernanda S. Povreslo, Andrew Corran, Anthony Lewis 2219-Pos Board B363 THE 2-PORE DOMAIN POTASSIUM CHANNEL TREK-1 REGULATES CYTO- KINE SECRETION FROM HUMAN ALVEOLAR EPITHELIAL CELLS INDEPEN- DENTLY OF POTASSIUM CURRENTS. Andreas Schwingshackl , Bin Teng, Marc Borsotto, Christopher M. Waters 2220-Pos Board B364 CALCIUM CURRENT PROPERTIES AND LEAK CONDUCTANCE IN MOUSE MUSCLE FIBERS OVEREXPRESSING A TYPE 1 HYPOKALEMIC PERIODIC PARALYSIS MUTANT L-TYPE CALCIUM CHANNEL. Clarisse Fuster, Jimmy Perrot, Christine Berthier, Vincent Jacquemond, Bruno Allard 2221-Pos Board B365 MICRODOMAIN-SPECIFIC REMODELLING OF AUTONOMIC REGULATION OF L-TYPE CALCIUM CHANNELS REVEALED BY SUPER-RESOLUTION SCAN- NING PATCH CLAMP IN RAT ATRIAL MYOCYTES IN HEART FAILURE. Alexey V. Glukhov , Marina Balycheva, Jose L. Sanchez-Alonso, Navneet Bhogal, Ivan Diakonov, Marta Mazzola, Giuseppe Faggian, Julia Gorelik 2222-Pos Board B366 CHARACTERISING THE EFFECTS OF A PEPTIDE DIRECTED AGAINST THE L- TYPE CA 2+ CHANNEL ON MITOCHONDRIAL FUNCTION IN HYPERTROPHIC CARDIOMYOPATHY. Livia C. Hool , Helena M. Viola, Victoria P.A. John- stone, Henrietta Cserne Szappanos, Tatiana Tsoutsman, Chris Semsarian, Christine Seidman 2223-Pos Board B367 SIMULATION OF L-TYPE CALCIUM CURRENTS USING DIFFERENT EXPERI- MENTAL DATA SOURCES: FROM CELL LINE TO IPS-DERIVED CARDIOMYO- CYTE. Ken Wang , Gary Mirams, Mark Davies, Antonello Caruso, Denis Noble, Ruben Alvarez-Sanchez, Antje Christine Walz, Thierry Lave, Franz Schuler, Thomas Singer, Liudmila Polonchuk 2224-Pos Board B368 EFFECT OF FLECAINIDE DERIVATIVES ON SARCOPLASMIC RETICULUM CA 2+ RELEASE CONFIRMS A LACK OF DIRECT ACTION ON THE CARDIAC RYANODINE RECEPTOR. Anita Alvarez-Laviada , Mark L. Bannister, Nia Lowri Thomas, Sammy A. Mason, Christo L. du Plessis, Abbygail T. Moran, David Neil-Hall, Hasnah Osman, Mark C. Bagley, Kenneth T. McLeod, Christopher H. George, Alan J. Williams 2225-Pos Board B369 FUNDAMENTAL GATING DEFECTS OF SUDDEN CARDIAC DEATH-LINKED MUTANT CARDIAC RYANODINE RECEPTORS DETERMINE CA 2+ RELEASE DYNAMICS IN CELLS. Shanna R. Hamilton , Chloe Maxwell, Christopher H. George, Saptarshi Mukherjee, Alan J. Williams, Nia L. Thomas 2226-Pos Board B370 LOSS OF MYOCARDIAL NNOS MEDIATED BY UPREGULATION OF MIR-31 IN HUMAN ATRIA CONTRIBUTES TO BEGETTING OF ATRIAL FIBRILLA- TION. Xing Liu , Svetlana Reilly, Ricardo Carnicer, Alice Recalde, Anna Muszkiewicz, Raja Jayaram, Maria Cristina Carena, Matilde Stefanini, Rohan Wijesurendra, Oliver Lomas, Rana Sayeed, George Krasopoulos, Alfonso Bueno-Orovio, Blanca Rodriguez, Barbara Casadei

2203-Pos Board B347 ASSESSING THE IN VITRO CARDIOTOXICITY OF SUPERPARAMAGNETIC ION OXIDE NANOPARTICLES (SPIONS). Roberta Gualdani , Andrea Guerrini, Elvira Fantechi, Claudio Sangregorio, Maria Rosa Moncelli 2204-Pos Board B348 HERG ION CHANNEL ACTIVITY MEASURED IN PLANAR LIPID BILAYER ARRAYS: RECONSTITUTION FROM EUKARYOTIC CELL-FREE EXPRESSION SYSTEM AND CELLULAR MEMBRANE PREPARATIONS. Ekaterina Zaitseva , Juan del Rio Martinez, Srujan Kumar Dondapati, Gerhard Baaken, Sönke Petersen, Stefan Kubick, Jan C. Behrends 2205-Pos Board B349 COMPREHENSIVE CARDIAC SAFETY SCREENING: PHARMACOLOGY OF STEM CELL-DERIVED CARDIOMYOCYTES USING HIGH-THROUGHPUT AUTOMATED PATCH CLAMP. Nadine Becker, Claudia S. Haarmann , Sonja Stölzle-Feix, Ilka Rinke, Markus Rapedius, Tom Götze, Timo Stengel, Andrea Brueggemann, Michael George, Niels Fertig 2206-Pos Board B350 NOVEL LOCAL ANESTHETICS DEMONSTRATE ISOMER-DEPENDENT ANAL- GESIA IN MICE. George Kracke , Monika VanGordon, Kuanysh Kabytaev, Yulia Sevryugina, Satish Jalisatgi, Fred Hawthorne 2207-Pos Board B351 USE-DEPENDENT BLOCK OF HUMAN CARDIAC SODIUM CHANNELS BY GS967. Franck Potet , Alfred L. George, Jr 2208-Pos Board B352 CONFORMATIONAL CHANGES OF THE NMDA RECEPTORS ASSOCIATED WITH ETHANOL-INDUCED INHIBITION. Hamid Reza Noori , Christian Mücksch, Herbert Urbassek 2209-Pos Board B353 EXPLORING STRUCTURAL INTERACTIONS OF TARANTULA TOXINS WITH LIPID MEMBRANES USING ROSETTA AND MOLECULAR DYNAMICS SIMU- LATION. Phuong T. Nguyen , Jon T. Sack, Toby W. Allen, Vladimir Yarov-Yarovoy 2210-Pos Board B354 VALIDATION OF KCA3.1 CHANNEL SMALL MOLECULES INTERACTION SITES PREDICTED BY ROSETTA. Hai M. Nguyen , Latika Singh, Heike Wulff, Vladimir Yarov-Yarovoy 2211-Pos Board B355 CARDIAC SMALL CONDUCTANCE CALCIUM-ACTIVATED K CHANNELS MAINTAIN REPOLARIZATION RESERVE IN A PHARMACOLOGICAL MODEL OF TYPE 3 LONG QT SYNDROME. Jum Suk Ko, Dechun Yin, Thomas H. Everett, Zhenhui Chen, Michael Rubart, Peng-Sheng Chen 2212-Pos Board B356 CALCIUM-ACTIVATED POTASSIUM CHANNELS IN THE MALARIA PARASITE ERYTHROCYTE CYCLE. Matthias Garten , Marika M. Kachman, Svetlana Glushakova, Joshua Zimmerberg 2213-Pos Board B357 SUPPRESSION OF KV2-MEDIATED CURRENTS BY THE ANTICONVULSANT RETIGABINE.  Jeroen I. Stas , Elke Bocksteins, Dirk J. Snyders 2214-Pos Board B358 USING VOLTAGE CLAMP FLUOROMETRY TO UNDERSTAND KCNQ CHAN- NEL PHARMACOLOGY. Robin Y. Kim , Stephan A. Pless, Harley T. Kurata 2215-Pos Board B359 A NEW KCNQ1 MUTATION AT THE S5 SEGMENT THAT IMPAIRS ITS ASSO- CIATION WITH KCNE1 IS RESPONSIBLE FOR SHORT QT SYNDROME. Alicia de la Cruz , Cristina Moreno, Anna Oliveras, Chiara Bartolucci, Juan R. Gimeno, Stefano Severi, Antonio Felipe, Teresa Gonzalez, Pier Lambiase, Carmen Valenzuela

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