Biophysical Society 60th Annual Meeting

2227-Pos Board B371 ISOPIMARIC ACID - A PROMISCUOUS ION CHANNEL MODULATOR AND A POTENTIAL DRUG CANDIDATE AGAINST ATRIAL FIBRILLATION. Sajjad Salari, Malin Silverå Ejneby , Johan Brask, Fredrik Elinder 2228-Pos Board B372 TOWARDS A STRUCTURAL UNDERSTANDING OF CANTú DISEASE ASSOCI- ATED GATING PERTURBATIONS IN THE KATP POTASSIUM CHANNEL.  Eva-Maria Plessl , Anna Stary-Weinzinger 2229-Pos Board B373 MATHEMATICAL MODELING OF HUMAN PANCREATIC ALPHA-CELLS: INSIGHT INTO THE ROLE OF SGLT2 IN GLUCAGON SECRETION. Morten G. Pedersen , Ingela Ahlstedt, Eva-Marie Andersson, Sven Göpel 2230-Pos Board B374 CFTR POTENTIATORS EXERT DIFFERENT EFFECTS ON HUMAN, MURINE, AND XENOPUS CFTR. Guiying Cui , Netaly Khazanov, Brandon B. Stauffer, Daniel T. Infield, Barry R. Imhoff, Hanoch Senderowitz, Nael A. McCarty 2231-Pos Board B375 CFTR ON AN AUTOMATED PATCH CLAMP SYSTEM. Rasmus B. Jacobsen, Naja Møller M. Sørensen 2232-Pos Board B376 SLC6A14 ENHANCES CFTR CHANNEL ACTIVITY IN THE CYSTIC FIBROSIS AFFECTED LUNG EPITHELIUM. Saumel Ahmadi , Sunny Xia, Michelle Di Paola, Wan Ip, Johanna Rommens, Tanja Gonska, Christine E. Bear 2233-Pos Board B377 IDENTIFICATION OF CARDIAC MITOCHONDRIAL CHLORIDE INTRACEL- LULAR CHANNEL (CLIC) PROTEINS AND THEIR PHYSIOLOGICAL FUNC- TION. Devasena Ponnalagu , Shubha Gururaja Rao, Piotr Bednarczyk, Yansheng Feng, Jason Farber, Rushi Thanawala, Ahmed Tafsirul Hussain, Jean Chrisostome Bopassa, Adam Szewczyk, Harpreet Singh Ligand-gated Channels II (Boards B378 - B398) 2234-Pos Board B378 CHARACTERIZATION OF THE INTERACTION OF THE INTRACELLULAR DO- MAIN OF 5-HT 3A RECEPTORS WITH THE CHAPERONE PROTEIN RIC-3.  Elham Pirayesh , Frankie Leung, Akash Pandhare, Michaela Jansen 2235-Pos Board B379 PENTAMERIC STRUCTURE OF THE SOLUBLE INTRACELLULAR DOMAIN OF 5-HT 3A RECEPTORS. Akash Pandhare , Petar N. Grozdanov, Michaela Jansen 2236-Pos Board B380 MASS SPECTROMETRY COUPLED WITH CROSSLINKING AS A STRUCTURAL TOOL FOR STRUCTURAL DETERMINATION OF HUMAN α1 GLYCINE RECEP- TOR. Rathna J. Veeramachaneni , Chelsee Donelan, Michael Cascio 2237-Pos Board B381 PRINCIPAL COMPONENTS FROM LIGAND-GATED ION CHANNEL STRUC- TURES ENABLE ENSEMBLE STUDIES OF MICROSECOND-SCALE TRANSI- TIONS. Ozge Yoluk , Laura Orellana, Edward J. Bertaccini, James R. Trudell, Erik Lindahl 2238-Pos Board B382 CATION-π INTERACTIONS: COMPUTATIONAL ANALYSES OF THE AROMAT- IC BOX MOTIF AND THE FLUORINATION STRATEGY FOR EXPERIMENTAL EVALUATION OF CYS-LOOP RECEPTORS AND RELATED STRUCTURES.  Matthew R. Davis , Dennis A. Dougherty 2239-Pos Board B383 EXPLORING THE BINDING OF GABA TO THE INSECT RDL RECEPTOR WITH METADYNAMICS. Federico Comitani , Vittorio Limongelli, Carla Molteni

2240-Pos Board B384 RELATIVE AFFINITIES OF POSITIVE AND NEGATIVE MODULATORS OF HETEROMERIC GABA(A) RECEPTORS FOR PSEUDO-SYMMETRIC INTER- SUBUNIT BINDING SITES. Sruthi Murlidaran , Reza Salari, Jérôme Hénin, Grace Brannigan 2241-Pos Board B385 IDENTIFYING GABA-A RECEPTOR MODULATORS THAT BIND TO INTERSUB- UNIT SITES IN THE GABA-A RECEPTOR TRANSMEMBRANE DOMAIN.  Selwyn S. Jayakar , Xiaojuan Zhou, Pavel Y. Savechenkov, Karol S. Bruzik, Keith W. Miller, Jonathan B. Cohen 2242-Pos Board B386 INTERACTIONS OF A PHOTOREACTIVE STEROID ANESTHETIC (F4N3- ALPHAXALONE) WITH HUMAN α1β3γ2 GABA-A RECEPTORS. David C. Chiara , Pavel Y. Savechenkov, Xiaojuan Zhou, Rooma Desai, Alex T. Stern, Yinghui Zhang, Stuart A. Forman, Karol S. Bruzik, Keith W. Miller, Jonathan Board B387 PULSED ELECTRON PARAMAGNETIC RESONANCE OF SPIN LABELED HUMAN GABA(A)RS FUNCTIONALLY RECONSTITUTED IN LIPID BILAYERS SUGGESTS THERE IS SPACE FOR LIPIDS BETWEEN THE SUBUNITS. Yinghui Zhang, Jessica L. Sarver, Xiaojuan Zhou, David S. Cafiso, Keith W. Miller 2244-Pos Board B388 VISIBLE-LIGHT ABSORBING, PHOTOLABILE, QUINONE-BASED PROTECTING GROUPS FOR ALCOHOLS AND AMINES. David P. Walton , Clinton J. Regan, Oliver S. Shafaat, Chris B. Marotta, Dennis A. Dougherty 2245-Pos Board B389 A SOLUBLE GABA A ρ1 INTRACELLULAR DOMAIN CHIMERA FOR STRUC- TURAL STUDIES. Laura J. Delin , Akash Pandhare, Katharine Jenkins, Michaela Jansen 2246-Pos Board B390 ALLOSTERIC GATING PATHWAYS FOR THE PENTAMERIC LIGAND-GATED ION CHANNEL GLIC. Bogdan Lev, Samuel Murail, Michael Thomas, Marc Baaden, Marc Delarue, Toby W. Allen 2247-Pos Board B391 INSIGHTS INTO GATING MOTIONS OF GLIC VIA PERTURBATION OF CRITI- CAL PROLINES WITH NON-CANONICAL AMINO ACID PROBES. Matthew Rienzo , Angela R. Rocchi, Stephanie D. Threatt, Dennis A. Dougherty, Sarah C. R. Lummis 2248-Pos Board B392 ELUCIDATING PROTON SENSITIVITY AND ACTIVATION IN THE GLOEO- BACTER VIOLACEUS LIGAND-GATED ION CHANNEL. Ákos Nemecz , Zaineb Fourati, Haidai Hu, Pierre-Jean Corringer, Marc Delarue 2249-Pos Board B393 A SINGLE MUTATION IN GLIC REVEALS BOTH THE POTENTIATING AND THE INHIBITORY NATURE OF PROPOFOL. Stephanie A. Heusser , Rebecca J. Howard, Iman Pouya, Göran Klement, Cecilia Borghese, R. Adron Harris, Erik Lindahl 2250-Pos Board B394 MOLECULAR INSIGHTS INTO ALLOSTERIC MODULATION OF GLIC GAT- ING BY MEMBRANE LIPIDS. Sandip Basak , Nicolaus Schmandt, Sudha Chakrapani 2251-Pos Board B395 RADIAL TILTING OF THE EXTRACELLULAR DOMAIN OF GLIC REVEALED BY EPR SPECTROSCOPY. Varun Tiwari , Abby M. Schuh, Candice S. Klug, Cynthia Czajkowski B. Cohen 2243-Pos

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