Biophysical Society 60th Annual Meeting

Platform Molecular Dynamics II 1:00 pm - 3:00 pm, Room 502A

2587-Plat 1:45 pm CARDIOMYOPATHY-ASSOCIATED MUTATION K15N IN TROPOMYOSIN AF- FECTS ITS INTERACTION WITH LEIOMODIN AND TROPOMODULIN. Mert Colpan, Dmitri Tolkatchev, Samantha Grover, Gregory L. Helms, John R. Cort, Natalia Moroz, Alla S. Kostyukova 2588-Plat 2:00 pm INTEGRATION OF CARDIAC TROPONIN I PHOSPHORYLATIONS TO MODU- LATE FUNCTION.  Hussam E. Salhi , Nicholas P. Gualtieri, Shane D. Walton, Elizabeth A. Brundage, Jonathan P. Davis, Brandon J. Biesiadecki 2589-Plat 2:15 pm CROSSTALK WITHIN CARDIAC TROPONIN COMPLEX WITH THE R145W MUTATION IN CARDIAC TROPONIN I.  Nikolai Smolin , Alexey V. Dvornikov, Jodi L. Martin, Seth L. Robia, Pieter P. de Tombe 2590-Plat 2:30 pm CMYBP-C PHOSPHORYLATION MODULATES SARCOMERE LENGTH- DEPENDENT CHANGES IN CARDIAC MUSCLE CONTRACTILE FUNCTION.  Ranganath Mamidi , Kenneth S. Gresham, Julian E. Stelzer 2591-Plat 2:45 pm IMPACT OF CGMP-PKG PATHWAY MODULATION ON TITIN PHOSPHORYLA- TION AND TITIN-BASED MYOCARDIAL PASSIVE STIFFNESS.  Nazha Hamdani , Melissa Herwig, Soraya Heopler, Doris Koesling, Marcus Kreuger, Michaela Kuhn, Wolfgang A. Linke Platform Ion Channels, Pharmacology, and Disease 1:00 pm - 3:00 pm, Room 515A Co-Chairs Aurelia Honerkamp-Smith, University of Cambridge, United Kingdom Harley Kurata, University of Alberta, Canada 2592-Plat 1:00 pm POSITIVE ALLOSTERIC MODULATION OF SK CHANNELS BY RILUZOLE.  Young-Woo Nam, Sara Ali, Stephen Chiang, Tia Alexander, Miao Zhang 2593-Plat 1:15 pm DEFINING THE MOLECULAR MECHANISMS OF SUBTYPE SPECIFIC KCNQ2/3 POTASSIUM CHANNEL ACTIVATORS. Wei-Ting (Alice) Wang , Michael Yau, Harley Kurata 2594-Plat 1:30 pm VOLTAGE-DEPENDENT ACCESSIBILITY OF PHOSPHORYLATION SITES AT THE CARBOXY-TERMINAL DOMAIN OF KV1.3 CHANNELS DETERMINES KV1.3-INDUCED CELL PROLIFERATION.  Teresa Pérez-García , Pilar Cidad, Laura Jiménez-Perez, Ines Alvarez-Miguel, Alba Santos-Hipolito, Esperanza Alonso, Miguel A. de la Fuente, José R. López-López 2595-Plat 1:45 pm USING UNNATURAL AMINO ACIDS TO PROBE THE MOLECULAR BASIS FOR HERG DRUG BLOCK.  Logan Macdonald , Robin Y. Kim, Harley T. Kurata, Christopher Ahern, David Fedida 2596-Plat 2:00 pm MANUAL PATCH-CLAMP RECORDING FOR MEDIUM-THROUGHPUT ION CHANNEL DRUG SCREENING: ASSAY VALIDATION BY SEARCHING FOR A BLOCKER OF NUCLEAR MONOVALENT CATIONIC CHANNEL.  Viktor Yarotskyy , Robert T. Dirksen 2597-Plat 2:15 pm ON THE RELATION BETWEEN HERG CHANNEL BLOCK IN CELL LINE AND ACTION POTENTIAL PROLONGATION IN HUMAN IPSC CARDIOMYOCYTES. Priyanka Saxena , Maria Hortigon-Vinagre, Stanislav Beyl, Igor Baburin,

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Co-Chairs Tristan Bereau, Max Planck Institute for Polymer Research, Germany Tobin Sosnick, University of Chicago 2576-Plat 1:00 pm RNA CONFORMATIONAL ENSEMBLES: NARROWING THE GAP BETWEEN EXPERIMENTS AND SIMULATIONS WITH METADYNAMICS.  Alejandro Gil-Ley , Sandro Bottaro, Giovanni Bussi 2577-Plat 1:15 pm APPLICATION OF THE STRING AND 2D HAMILTONIAN REPLICA EXCHANGE UMBRELLA SAMPLING METHODS FOR THE STUDY OF CONFORMATIONAL CHANGES IN THE BACTERIAL ASPARTATE TRANSPORTER GLT(PH).  Hristina R. Zhekova , Bogdan Lev, Sergei Noskov 2578-Plat 1:30 pm EDUCATION TRAVEL AWARDEE QUANTIFYING MACROMOLECULAR TRANSITION PATHS WITH PATH SIMI- LARITY ANALYSIS.  Sean L. Seyler , Avishek Kumar, Taylor Colburn, Michael F. Thorpe, Oliver Beckstein 2579-Plat 1:45 pm INVESTIGATING KINETICS OF CONFORMATIONAL CHANGE USING MOLEC- ULAR DYNAMICS AND MILESTONING.  Hiroshi Fujisaki , Ayori Mitsutake 2580-Plat 2:00 pm IMPROVED KINETICS OF MOLECULAR SIMULATIONS USING BIASED MAR- KOV STATE MODELS.  Joseph F. Rudzinski, Kurt Kremer, Tristan Bereau 2581-Plat 2:15 pm UPSIDE: A NEW DYNAMICS METHOD CAPABLE OF COOPERATIVE DE NOVO PROTEIN FOLDING IN CPU-HOURS.  Tobin R. Sosnick , John M. Jumper, Karl F. Freed 2582-Plat 2:30 pm MODELLING CYSTEINE DISULFIDE EXCHANGE REACTIONS BY MOLECULAR DYNAMICS SIMULATIONS.  Katra Kolšek , Camilo Aponte-Santamaría, Frauke Gräter 2583-Plat 2:45 pm CLASSICAL DENSITY FUNCTIONAL THEORY FOR IMPLICIT SOLVENT SIMU- LATIONS.  Eric A. Mills , Steven S. Plotkin Platform Cardiac Muscle Regulation 1:00 pm - 3:00 pm, Room 502B Co-Chairs Nazha Hamdani, Ruhr University Bochum, Germany Alla Kostyukova, Washington State University 2584-Plat 1:00 pm DOES TROPOMYOSIN SLIDE OR ROLL OVER F-ACTIN DURING REGULA- TORY TRANSITIONS? Michael Rynkiewicz, Veronika Schott, Marek Orzechowski, Stefan Fischer, William Lehman 2585-Plat 1:15 pm TROPOMYOSIN DYNAMICS DURING CARDIAC THIN FILAMENT ACTIVA- TION AS GOVERNED BY A MULTI-WELL ENERGY LANDSCAPE.  Yasser Aboelkassem , Natalia Trayanova 2586-Plat 1:30 pm INVESTIGATING COOPERATIVITY USING A NEW BIOPHYSICALLY DETAILED CARDIAC CONTRACTION MODEL.  Sander Land , Steven A. Niederer

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