Biophysical Society 60th Annual Meeting

Protein Structure and Conformation IV (Boards B1 - B13) 2624-Pos Board B1 CHANGES IN βL-CRYSTALLIN AND OVALBUMIN DUE TO EXPOSURE TO GREEN AND RED LIGHT.  Juan Horacio Espinoza Rodríguez , Hilda Mercado Uribe 2625-Pos Board B2 THE EFFECT OF SMALL MOLECULES ON EARLY AND LATE EVENTS OF ALPHA SYNUCLEIN AGGREGATION IN SOLUTION AND INSIDE LIVING CELLS. Amrita Kundu , Sumanta Ghosh, Krishnananda Chattopadhyay 2626-Pos Board B3 MENADIONE SUPPRESSES AMYLOID FIBRILLOGENESIS AND CYTOTOXICI- TY: IMPLICATION IN THE TREATMENT OF SYSTEMIC AMYLOIDOSIS. Parvez Alam , Sumit K. Chaturvedi, Mohd K. Siddiqi, Rizwan H. Khan 2627-Pos Board B4 OLIGOMERIC STRUCTURES OF AN AGGREGATION-TRIGGERING FRAG- MENT OF SOD1 PROTEIN. Qingwen Zhang , Yu Zou 2628-Pos Board B5 STRUCTURAL REARRANGEMENT FROM OLIGOMER TO FIBRIL IN A DE- SIGNED AMPHIPHILIC PEPTIDE. Heng Chi , Timothy A. Keiderling 2629-Pos Board B6 STUDY OF MOLECULAR MECHANISMS OF AMYLOID β-PEPTIDE VARIANTS AGGREGATION IN PRESENCE OF SURFACTANTS. Michalina Skupin , Maciej Kozak 2630-Pos Board B7 ANOMALOUS IRREVERSIBLE “CONVERSION” OF TAG-BFP FLUORESCENCE SPECTRA IN THE PRESENCE OF TAG-RFP: POSSIBLE MODEL OF PRION IN- TERACTIONS. Andrey Samsonov , Andrea Klarich, Nathan Zenser, Hongyi Zhang, Dmitry Malkov 2631-Pos Board B8 COMPARATIVE CONFORMATIONAL DYNAMICS OF CELLULAR PRION PRO- TEINS TOWARDS ELUCIDATING THE SPECIES BARRIER. Robyn Hamada , Jesse Woo, Ronald Shikiya, Patricia Soto 2632-Pos Board B9 EXPLORING THE ORB2 FIBRIL CORE. Alexander S. Falk , Silvia A. Cervantes, Maria A. Conrad-Soria, Thalia H. Bajakian, Ansgar B. Siemer 2633-Pos Board B10 CONFORMATIONAL SHIFTS IN HUNTINGTIN EXON 1 MONOMER ARE DEPENDENT ON TEMPERATURE AND POLYGLUTAMINE LENGTH. Natalie C. Kegulian, Mario J. Isas , Sean S. Chung, Nitin K. Pandey, Jose M. Bravo, Ralf Langen 2634-Pos Board B11 ASSEMBLY MECHANISM AND NANOMECHANICS OF Aβ IN ALZHEIMER’S DISEASE. Hsien-Shun Liao, Catherine Stark , James B. Yao, Havisha Garimella, Paul D. Smith, Curtis W. Meuse, Albert J. Jin 2635-Pos Board B12 INVESTIGATION ON PLEXIN RHO GTPASE BINDING DOMAIN (RBD) BIND- ING WITH SMALL RHO GTPASES USING MOLECULAR DYNAMICS SIMULA- TIONS. Liqun Zhang , Thomas Centa, Matthias Buck 2636-Pos Board B13 CONFORMATIONAL PLASTICITY OF THE MAGE-A3 PROTEIN AS A THERA- PEUTIC STRATEGY IN MULTIPLE MYELOMA. Roman Osman , Hearn J. Cho, Anna H. Mei, Joseph A. Newman, Opher Gileadi

Protein Structure, Prediction, and Design (Boards B14 - B40) 2637-Pos Board B14 ENHANCING THE COEVOLUTIONARY SIGNAL. Travis A. Hoppe , Pengfei Tian, Robert Best 2638-Pos Board B15 ALTERNATIVE APPROACH TO PROTEIN STRUCTURE PREDICTION BASED ON SEQUENTIAL SIMILARITY OF PHYSICAL PROPERTIES. Yi He , S. Rackovsky, Yanping Yin, Harold A. Scheraga 2639-Pos Board B16 PROTEIN RETHREADING. Salem Faham , Sandra Poulos, Austin Yu, Sayeh Agah 2640-Pos Board B17 PREDICTION OF PROTEIN RIGID DOMAINS AND HINGE RESIDUES BASED ON GRAPH THEORY AND ELASTIC NETWORK MODEL.  Julian Lee , Jun Sim, Jaehyun Sim, Eunsung Park 2641-Pos Board B18 CHARACTERIZING THE STATISTICAL PROPERTIES OF PROTEIN SURFACES.  Ji Hyun Bak , Anne-Florence Bitbol, William Bialek 2642-Pos Board B19 A NOVEL IN SILICO 4D GEOMETRICAL MEASURE OF THE ACTIVE SITE CORRELATES WITH THE ENZYMATIC ACTIVITY OF HCV NS3 PROTEASE; IMPLICATIONS IN CATALYSIS AND DRUG DESIGN. Mohammad S. Yousef , Hamzah Hamad, Jeremy Thurston, Thomas Teague, Edward Ackad 2643-Pos Board B20 TENSILE MECHANICS OF COILED COIL PROTEIN STRUCTURES. Mojtaba Jokar, Korosh Torabi 2644-Pos Board B21 DESIGN AND ENGINEERING OF NANOPORES WITH EMERGENT FUNC- TIONS. Giovanni Maglia 2645-Pos Board B22 ON THE COMBINATION OF RESTRAINT-DRIVEN DOCKING OF FLEXIBLE PEPTIDES TO ION CHANNELS - LESSONS LEARNT FROM THE COMPLEX FORMED BY THE SPIDER VENOM PCTX1 AND THE ACID SENSING ION CHANNEL1. Evelyne Deplazes , Josephine Davies, Alexandre M. J. J. Bonvin, Alan E. Mark 2646-Pos Board B23 DE NOVO DESIGNED PEPTIDES INHIBIT THE CYTOKINES BINDING TO THEIR RECEPTORS FROMMOLECULAR SIMULATIONS AND IN VITRO EX- PERIMENTS. Yi Chung , Shinn-Jong Jiang, Je-Wen Liou, Hao-Jen Hsu 2647-Pos Board B24 MUTUALLY EXCLUSIVE FOLDING AND ITS ESCAPE HATCH: DESIGNING FUNCTIONAL POLYMERS BY ENGINEERED DOMAIN SWAPPING.  Joshua M. Karchin , Jeung-Hoi Ha, Stewart N. Loh 2648-Pos Board B25 COMBINING FRAGMENTATION OF AN AMINO ACYL TRNA SYNTHETASE WITH FUSION TO INTERACTING PROTEINS TO INCREASE CONTROL OVER PROTEIN METABOLIC LABELING. Emily E. Thomas 2649-Pos Board B26 DE NOVO DESIGN AND IN SILICO OPTIMIZATION OF ANTIBODY-LIKE BIND- ERS TARGETING EBOLA VIRAL ANTIGEN. Muyun Lihan , Boon Chong Goh, Tong Li, Costas D. Maranas, Klaus Shulten

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