Biophysical Society 60th Annual Meeting

2715-Pos Board B92 DISTRIBUTION OF IMMOBILIZED ENZYMES ON THE SURFACE AND INTO THE MESOPOROUS SILICA PARTICLE. Pegah S. Nabavi Zadeh , Björn Åkerman Intrinsically Disordered Proteins (IDP) and Aggregates: Aß, Tau, and α -Synuclein (Boards B93 - B113) 2716-Pos Board B93 WHY PRESSURE IS BAD FOR YOUR BRAIN? HYDROSTATIC PRESSURE PROMOTES AGGREGATION OF ALPHA-SYNUCLEIN IN CELLS. Urszula P. Golebiewska , Suzanne Scarlata 2717-Pos Board B94 AGGREGATION AND FIBRILLATION OF α-SYNUCLEIN BY POLYMORPH PATCHY PARTICLES.  Ioana M. Ilie , Wouter K. den Otter, Wim J. Briels 2718-Pos Board B95 ALPHA-SYNUCLEIN AND ITS INTERACTION WITH CYTOSKELETON (ASSOCI- ATED) PROTEINS: IMPLICATIONS IN PARKINSON’S DISEASE. Senthil Kumar Thangaraj , Lisanne Dijk, Mireille Claessens 2719-Pos Board B96 MOLECULAR DYNAMICS SIMULATIONS OF ALPHA-SYNUCLEIN ENSEMBLE FRET MEASUREMENTS FROM DIFFERENT FORCE FIELDS. Reinhard Klement, Timo Graen , Asaf Grupi, Elisha Haas, Helmut Grubmüller 2720-Pos Board B97 UNCONVENTIONAL CHAPERONE INHIBITS AMYLOID FORMATION BY PROMOTING OFF-PATHWAY AGGREGATION. Illes-Toth Eva, Shah Maliha, Wu Nelson, Verzini Silvia, Selenko Philipp, Wanker E. Erich, Jan Bieschke 2721-Pos Board B98 EDUCATION TRAVEL AWARDEE MULTI-TRGET THERAPEUTIC POTENTIAL OF GREEN TEA CATECHINS AND BLACK TEA THEAFLAVINS TOWARD Aβ-INDUCED SIGNAL PATHWAYS INVOLVED IN ALZHEIMER’S DISEASE. Shelby E. Chastain , Melissa Moss 2722-Pos Board B99 EFFECT OF ACIDIC PH ON THE STABILITY OF ALPHA-SYNUCLEIN DI- MERS. Zhengjian Lv , Alexey V. Krasnoslobodtsev, Yuliang Zhang, Daniel Ysselstein, Jean-Christophe Rochet, Scott C. Blanchard, Yuri L. Lyubchenko 2723-Pos Board B100 THE INTERPLAY OF INTRINSIC DISORDER AND MACROMOLECULAR CROWDING ON α-SYNUCLEIN FIBRIL FORMATION. Nobu C. Shirai , Macoto Kikuchi 2724-Pos Board B101 ASSESSING N-TERMINAL MODIFICATIONS ON ALPHA-SYNUCLEIN STRUC- TURE AND FUNCTION. Siobhan Toal , David DeWitt, Adam Trexler, Mark Brown, Elizabeth Rhoades 2725-Pos Board B102 EFFICIENT LIPID PEROXIDATION CATALYZED BY AMYLOID-BETA-COPPER COMPLEX: OBSERVATION OF CHEMICAL OSCILLATION AND CHAOS.  Ciaran McFarlane, Paul Girvan, Thomas Branch, Liming Ying 2726-Pos Board B103 SELF-ASSEMBLY OF FULL-SIZE AMYLOID BETA 40 PROTEINS IN DI- MERS. Mohtadin Hashemi , Yuliang Zhang, Zhengjian Lv, Yuri L. Lyub- chenko 2727-Pos Board B104 X-RAY DIGITAL AGGREGATED DYNAMICS OF INTRINSICALLY DISORDERED PROTEINS. Naruki Hara , Yufuku Matsushita, Keigo Ikezaki, Hiroshi Sekiguchi, Naoya Fukui, Yasushi Kawata, Yuji C. Sasaki

2701-Pos Board B78 STRUCTURAL AND BIOCHEMICAL INVESTIGATIONS ON THE CATALYTIC MECHANISM OF PYRIDOXAL KINASE (PDXK) FROM SALMONELLA TYPHIMURIUM AND ITS INTERACTIONS WITH PLP-DEPENDENT EN- ZYMES. G. Deka , J. F. Benazir, J. N. Kalyani, H. S. Savithri, M.R.N. Murthy 2702-Pos Board B79 MOLECULAR BASIS FOR COHESIN ACETYLATION BY ESTABLISHMENT OF SISTER CHROMATID COHESION N-ACETYLTRANSFERASE (ESCO1). Yadil- ette Rivera-Colon , AndrewMaguire, Glen P. Liszczak, Ronen Marmorstein 2703-Pos Board B80 ORIGINS OF CATALYTIC SPECIFICITY IN BACTERIAL OLIGOSACCHARYL- TRANSFERASE. Brittany R. Morgan , Francesca Massi 2704-Pos Board B81 MOLECULAR MECHANISM OF THE CATALYTIC REACTION OF NO REDUC- TASE REVEALED BY NOVEL TIME-RESOLVED VISIBLE/IR ABSORPTION SPECTROMETERS WITH MICROFLUIDIC DEVICE. Tetsunari Kimura , Hanae Takeda, Shoko Ishii, Takehiko Tosha, Yoshitsugu Shiro, Minoru Kubo 2705-Pos Board B82 DROPLET-BASED MICROFLUIDICS FOR MEASURING ENZYMATIC AC- TIVITIES: APPLICATION TO L-ASPARAGINASE USED IN ANTILEUKEMIC THERAPY. Manfred W. Konrad , Christos S. Karamitros, Joanan Lopez Morales, Jean-Christophe Baret 2706-Pos Board B83 EDUCATION TRAVEL AWARDEE TRANSGLUTAMINASE FACTOR XIII CROSS-LINKS REACTIVE GLUTAMINES IN DISORDERED REGIONS OF FIBRINOGEN αC. Kelly Njine Mouapi , Kerrie A. Smith, Robert A.S Ariens, Helen Philippou, Muriel C. Maurer 2707-Pos Board B84 CHARACTERIZATION OF THE PYRUVATE OXIDASE CIDC FROM S. AURE- US. Xinyan Zhang , Kenneth Bayles, Sorin Luca 2708-Pos Board B85 PHOSPHODIESTERASE 5 SIGNALS THROUGH HIPPO/TAZ PATHWAY IN MAINTAINING STEMNESS OF PROSTATE CANCER CELLS. Naihua Liu , Xing Ji, Ximei Wu 2709-Pos Board B86 THE NEET PROTEINS MEDIATE IRON-SULFUR CLUSTER TRANSPORT FROM THE MITOCHONDRIA TO CYTOSOLIC PROTEINS. Colin H. Lipper , Mark L. Paddock, Rachel Nechushtai, Patricia A. Jennings 2710-Pos Board B87 KINETIC AND STRUCTURAL ANALYSES OF A DYNAMIN MECHANOEN- ZYME. Blake Hill , Nolan Kennedy 2711-Pos Board B88 KINETIC DISSECTION OF THE PRE-EXISTING CONFORMATIONAL EQUILIB- RIUM IN THE TRYPSIN FOLD. Austin D. Vogt, Pradipta Chakraborty , Enrico Di Cera 2712-Pos Board B89 INFLUENCE OF DIFFUSION ON THE KINETICS OF MULTISITE PHOSPHORY- LATION.  Irina V. Gopich , Attila Szabo 2713-Pos Board B90 EFFECTS OF METAL SUBSTITUTION IN HDAC8 AND IMPLICATIONS FOR KINETICS. Nathan Gallup , Michael Nechay 2714-Pos Board B91 SYNTHESIZING CAGED-NAD MOLECULES TO CONDUCT LAUE TIME- RESOLVED CRYSTALLOGRAPHY MEASUREMENTS ON HMGCOA REDUC- TASE. Vatsal Purohit , Farbod Salahi, Nic Steussy, Paul Helquist, Olaf Weist, Cynthia Stauffacher

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