Biophysical Society 60th Annual Meeting

2728-Pos Board B105 TAU MEDIATES WIDELY-SPACED MICROTUBULE BUNDLES THROUGH LOCAL POLYION ATTRACTIONS AT THE MIDPLANE LAYER: A NOVEL, FUNC- TIONAL MECHANISM FOR INTRINSICALLY DISORDERED PROTEINS. Peter J. Chung , Chaeyeon Song, Joanna Deek, Herbert P. Miller, Youli Li, Leslie Wilson, Stuart C. Feinstein, Cyrus R. Safinya 2729-Pos Board B106 EDUCATION TRAVEL AWARDEE Aβ FIBRILS ACT AS AQUEOUS PORES: A MOLECULAR DYNAMICS STUDY. Sachin R. Natesh , Stephen C. Meredith, Tobin R. Sosnick, Karl F. Freed, Esmael J. Haddadian 2730-Pos Board B107 DANCING WITH STRINGS: THE CONFORMATIONAL DYNAMICS OF VQIXXK MOTIFS WITHIN TAU PROTEIN IN MONOMER, FIBRIL AND HYPER-PHOS- PHORYLATED FILAMENT STATES. Buyong Ma , Guanghong Wei, Jie Zhen, Ruth Nussinov 2731-Pos Board B108 THE CONFORMATION OF Aβ-PEPTIDE AGGREGATES ON 2D SURFACES IS DIFFERENT THAN IN SOLUTION: A MOLECULAR DYNAMICS STUDY. Sachin R. Natesh, Kark F. Freed, Esmael J. Haddadian 2732-Pos Board B109 TAU BINDS TO MULTIPLE TUBULIN DIMERS WITH HELICAL STRUC- TURE. Xiaohan Li , Jacob A. Culver, Elizabeth Rhoades 2733-Pos Board B110 THE DISPARATE EFFECTS OF TWO MOLECULAR CHAPERONES ON TAU AMYLOID FORMATION. Hannah E.R. Baughman , Amanda F. Clouser, Rachel E. Klevit, Abhinav Nath 2734-Pos Board B111 BINDING-ACTIVATED SUPERRADIANT PROBES FOR AMYLOID IN SOLU- TION AND TISSUE. Patrick Donabedian , Nicole Maphis, Shanya Jiang, Kiran Bhaskar, David Whitten, Eva Chi 2735-Pos Board B112 AMYLOID AGGREGATION OF AMYLIN: GAIN OF FUNCTION ALONG AG- GREGATION PATHWAY? Anoop Rawat , Debanjan Bhowmik, Barun Kumar Maity, Sudipta Maiti 2736-Pos Board B113 AMYLOID-β(1-42)OLIGOMER MODELS DEVELOPED USING COMBINED SOLID STATE NMR AND SEQUENCE SPECIFIC HYDROXYL RADICAL FOOT- PRINTING DATA. Alexandra Klinger , Cong Guo, Huan-Xiang Zhou, Anant Paravastu, Janna Kiselar, Andrew J. Nix, Terrone L. Rosenberry Investigating the Properties of Intrinsically Disordered Proteins (IDP) (Boards B114 - B140) 2737-Pos Board B114 NMR INVESTIGATION OF CALMODULIN INDUCED FOLDING IN THE REGU- LATORY DOMAIN OF CALCINEURIN. Dinesh K. Yadav 2738-Pos Board B115 PROTEIN DESIGN FOR DECREASED DISORDER: SHERP AS AN EXEMPLAR PROTEIN. Elliot Drew , David T. Jones, B.A. Wallace 2739-Pos Board B116 STRUCTURAL MODELS OF AN INTRINSICALLY DISORDERED PROTEIN ADAPTED FOR BACTERIAL SECRETION. Darragh Patrick O’Brien, Belen Hernandez, Dominique Durand, Veronique Hourdel, Ana Cristina Sotomayor Pérez, Patrice Vachette, Mahmoud Ghomi, Julia Chamot-Rooke, Daniel Ladant, Sébastien Brier, Alexandre Chenal

2740-Pos Board B117 MULTI-COLOR SINGLE MOLECULE FRET STUDY OF INTRINSICALLY DISOR- DERED PROTEIN BINDING. Hoi Sung Chung , Fanjie Meng, Jae-Yeol Kim, John M. Louis 2741-Pos Board B118 CHARACTERIZATION OF AN INTRINSIC DISORDER DOMAIN AND FUNC- TIONAL ACTIVITY OF CHIZ MEMBRANE PROTEIN FROMMYCOBACTE- RIUM TUBERCULOSIS. Cristian A. Escobar , Riqiang Fu, Timothy A. Cross 2742-Pos Board B119 EXPERIMENTAL POLYPROLINE II PROPENSITIES DESCRIBE SEQUENCE- DEPENDENT VARIABILITY IN THE HYDRODYNAMIC SIZE OF INTRINSICALLY DISORDERED PROTEINS. Steven T. Whitten 2743-Pos Board B120 RESCUING THE OVER-COLLAPSE OF INTRINSICALLY DISORDERED PRO- TEINS USING A FORCE FIELD DERIVED BY A NEW PARADIGM. Davide Mercadante , Sigrid Milles, Gustavo Fuertes, Dmitri Svergun, Edward A. Lemke, Frauke Gräter 2744-Pos Board B121 PROTEOMIC AND BIOPHYSICAL ANALYSIS OF POLAR TRACTS. Kiersten M. Ruff , Alex S. Holehouse, Mary G.O. Richardson, Rohit V. Pappu 2745-Pos Board B122 SINGLE-MOLECULE DISSECTION OF THE CONFORMATIONS, DYNAMICS AND BINDING OF THE DISORDERED 4E-BP2 PROTEIN. Zhenfu Zhang , Alaji Bah, Hamda Sajjad, Julie D. Forman-Kay, Claudiu C. Gradinaru 2746-Pos Board B123 LC8 MOTIF RECOGNITION: INSIGHTS FROM THE LC8-CHICA COM- PLEX. Sarah Clark 2747-Pos Board B124 NMR-BASED MOLECULAR VIEW OF THE BIOLOGY AND BIOPHYSICS OF WIP, AN INTRINSICALLY DISORDERED PROTEIN. Eva Rozentur-Shkop, Hadassa Shaked, Jordan Chill 2748-Pos Board B125 EDUCATION TRAVEL AWARDEE DYNAMICS OF CONTACT FORMATION IN DISORDERED POLYPEPTIDES.  Gül H. Zerze , Robert B. Best, Jeetain Mittal 2749-Pos Board B126 CHEMICAL PERTURBATION OF AN INTRINSICALLY DISORDERED REGION OF TFIID DISTINGUISHES DE NOVO TRANSCRIPTION INITIATION FROM RE- INITIATION. Zhengjian Zhang , Zarko Boskovic, Mahmud Hussain, Wenxin Hu, Carla Inouye, Angela Koehler, Stuart Schreiber, Robert Tjian 2750-Pos Board B127 RNA-BINDING DOMAIN DISORDER MODULATES THE RNA DESTABILIZING ACTIVITY IN THE TTP FAMILY OF PROTEINS. Laura M. Deveau, Francesca Massi 2751-Pos Board B128 PROBING THE CONFORMATIONAL ENSEMBLE OF A BACTERIAL ANTI- TOXIN THROUGH MOLECULAR DYNAMICS SIMULATIONS AND MASS SPECTROMETRY. Virginia M. Burger , Albert Konijnenberg, Alexandra Vanderwelde, Frank Sobott, Remy Loris, Collin M. Stultz 2752-Pos Board B129 THE ROLE OF INTRINSIC DISORDER IN THE MOLECULAR MECHANISM OF NUCLEAR TRANSPORT. Laura K. Maguire , Kathryn Wall, Geoff Armstrong, Kaushik Dutta, Samuel Sparks, Deniz B. Temel, Alia Kamal, Jaclyn Tetenbaum-Novatt, Michael P. Rout, David Cowburn, Loren Hough 2753-Pos Board B130 ELUCIDATING THE MECHANISM OF RECOGNITION AND BINDING OF PROTEIN KINASE INHIBITOR BY PROTEIN KINASE A USING NMR AND FLUORESCENCE SPECTROSCOPY. Geoffrey Li , Cristina Olivieri, Matthew Neibergall, Jonggul Kim, Susan Taylor, Joseph Muretta, Gianluigi Veglia

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