Biophysical Society 60th Annual Meeting

Friday, February 26 Exhibitor Registration 8:00 am–5:00 pm, West Lobby Drug Discovery Satellite Meeting XVI 8:00 am–5:00 pm, Room 411

11:00 am IDENTIFICATION AND CHARACTERIZATION OF NOVEL NMDA RECEPTOR POSITIVE ALLOSTERIC MODULATORS (PAMS).  David Hackos 11:30 am AUTOMATED ELECTROPHYSIOLOGY FOR TRANSLATIONAL CARDIAC MUSCLE. Liudmila Polonchuk and Ken Wang 12:00 pm lunch (provided) SESSION III Chair, Eugenia Jones 1:00 pm THE COMBINED USE OF ION CHANNEL STUDIES AND HUMAN IPS-DE- RIVED CARDIAC MYOCYTES IN PRECLINICAL SAFETY ASSESSMENT.  Alison Easter 1:30 pm INVESTIGATION OF POTASSIUM CHANNEL FUNCTION UTLIZING HUMAN iPSC-DERIVED NEURONS. Matthew Fuller 2:30 pm AUTOMATED ELECTROPHYSIOLOGY AS A PLATFORM FOR BIOPHYSICAL CHARACTERIZATION AND ION CHANNEL DRUG DISCOVERY.  Sophia Lin 3:00 pm break SESSION IV Chair. Richard Kondo 3:30 pm HUMAN iPS CELL-DERIVED CARDIOMYOCYTES AS A MODEL FOR CHARAC- TERIZATION OF NEW LQT SYNDROMMUTATION. Roselle Gélinas 4:00 pm COUPLING HIGH CAPACITY ELECRROPORATION WITH AUTOMATED PATCHY CLAMP RECORDING FOR FUNCTONAL ANNOTATION OF HUMAN ION CHANNEL VARIANTS.  Alfred George 4:30 pm Speaker to be announced 2:00 pm AUTOMATED PATCH CLAMP ASSAYS FOR STATES DEPENEDENT ION CHAN- NEL MODULATORS. Rok Cerne

F R I D A Y

Sponsored by Axiogenesis, Sophion together with Biolin Scientific, Cellular Dynamics International, Charles River, Maxcyte Inc, Molecular Devices LLC, Nanion Technologies GmBH Ion channels are an important class of therapeutic drug targets, and mu- tations in ion channel genes are found to be responsible for an increasing number of diseases. While conventional electrophysiological techniques permit the most detailed and direct study of ion channel function, they are limited due to the manual nature of the method and their low throughput. Because of this, ion channels remain an underrepresented target class for drug discovery. But the advent of automated electro- physiological systems with higher throughput has begun to revolutionize ion channel drug discovery. This symposium focuses on the emerging technology of automated electrophysiology and how it is changing the face of ion channel drug discovery. Speakers from industry and academia will discuss the development and potential of these new technologies, present experimental results obtained using these systems and discuss the impact these technologies are having on ion channel drug discovery. Co-Chairs Niels Fertig, Nanion Technologies GmbH Jeff Webber, Molecular Devices LLC Eugenia Jones, Cellular Dynamics International Richard Kondos, Sophion – Biolin Scientific 8:30 am WETWARE IN THE LOOP: REALTIME MODELLING USING DYNAMIC CLAMP FOR SAFETY AND DRUG DISCOVERY.  Steve Petrou 9:00 am GIGASEAL AUTOMATED PATCH-CLAMP RECORDINGS OF ION CHANNEL ACTIVITY EXPRESSED IN CELL LINES AND NATIVE CELLS.  Arturo Picones 9:30 am NEXT GENERATION ELECTROPHYSIOLOGY: COMPARISON OF PLATFORMS TO PROGRESS EFFICACY AND LIABILITY CAPABILITY AT ASTRAZENECA.  Matthew Bridgland-Taylor 10:00 am break SESSION II Chairm, Jeff Webber 10:30 am OPTICAL METHODS FOR EXAMINING EXCITATION-CONTRACTION COU- PLING IN IPS-DERIVED CARDIOMYOCYTES AND THEIR APPLICATION TO MEDIUM/HIGH THROUGH-PUT ASSAYS.  Godfrey Smith 7:30 am registration 8:00 am introduction SESSION I Chair, Niels Fertig

5:00 pm

closing remarks Richard Kondo

New Council Orientation 3:00 pm - 4:30 pm, J.W. Marriott - Plaza III Registration Open 3:00 pm - 5:00 pm, West Lobby Joint Council Reception, Dinner, and Meeting 5:00 pm - 9:00 pm, J.W. Marriott - Plaza I & II

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