Biophysical Society 60th Annual Meeting

162-Plat

152-Plat 12:30 pm FORCE SENSING BY THE VASCULAR PROTEIN VON WILLEBRAND FAC- TOR IS TUNED BY A STRONG INTERMONOMER INTERACTION.  Jochen P. Mueller , Salomé Mielke, Achim Löf, Tobias Obser, Christof Beer, Diana A. Pippig, Willem Vanderlinden, Reinhard Schneppenheim, Martin Benoit Platform Membrane Active Peptides and Toxins 10:45 am - 12:45 pm, Room 501ABC Co-Chairs Estefania Mulvihill, Eidgenössische Technische Hochschule Zürich, Switzerland Marc-Antoine Sani, University of Melbourne, Australia 153-Plat 10:45 am A PORE MODEL OR THE CARPET MODEL? THE MODE OF ACTION OF AMPS ON E. COLI SPHEROPLASTS.  Yen Sun, Tzu-Lin Sun, Huey W. Huang 154-Plat 11:00 am PROBING THE ANTIMICROBIAL ACTION OF POLYMYXIN B1 AND MELITTIN VIA COARSE-GRAINED MOLECULAR DYNAMICS SIMULATIONS.  Damien F. Jefferies , Pin-Chia Hsu, Syma Khalid 155-Plat 11:15 am THE DISRUPTIVE STATE OF THE MEMBRANE ACTIVE ANTIMICROBIAL PEPTIDE PISCIDIN 1 INVESTIGATED BY MULTI-μS ALL-ATOM SIMULATIONS AND SOLID-STATE NMR: SURFACE DEFECTS ARE FAVORED OVER STABLE PORES.  B. Scott Perrin Jr , Riqiang Fu, Myriam Cotten, Richard W. Pastor 156-Plat 11:30 am DIRECTLY OBSERVING THE LIPID-DEPENDENT SELF-ASSEMBLY AND PORE FORMING MECHANISM OF THE CYTOLYTIC TOXIN LISTERIOLISYN O.  Estefania S. Mulvihill , Katharina van Pee, Stefania Mari, Daniel J. Mueller, Özkan Yildiz 157-Plat 11:45 am LIPID-PROTEIN PARTNERING DURING PORE FORMATION OF FRAGACEA- TOXIN C.  Koldo Morante , Jose M. M. Caaveiro, Kouhei Tsumoto 158-Plat 12:00 pm INHIBITION OF RTX TOXIN ACTIVITY BY THE NUCLEAR STAIN, DRAQ5.  Angela C. Brown , Joshua Webb 159-Plat 12:15 pm MEMBRANE-BINDING PROPERTIES OF GATING-MODIFIER AND PORE BLOCKING TOXINS: MEMBRANE INTERACTION IS NOT A PREREQUISITE FOR MODIFICATION OF CHANNEL GATING.  Evelyne Deplazes , Sónia Troeira Henriques, Glenn F. King, David J. Craik, Alan E. Mark, Christina I. Schroeder 160-Plat 12:30 pm STRUCTURAL CHANGES IN LIPID MODEL MEMBRANES INDUCED BY THE FUNGAL PEPTIDE TOXIN ECE1-III.  Julia Wernecke , Laura Paulowski, Bernhard Hube, Oliver H. Seeck, Thomas Gutsmann Platform Cardiac Smooth and Skeletal Muscle Electrophysiology 10:45 am - 12:45 pm, Room 511ABC Co-Chairs Edward Lakatta, NIH Eric Sobie, University of Maryland Biotechnology Institute 161-Plat 10:45 am SUBSTANTIAL CELL-TO-CELL HETEROGENEITY OF ION CURRENTS IS AN ES- SENTIAL CHARACTERISTIC OF THE SINOATRIAL NODE.  Oliver J. Monfredi , Bruce Ziman, Mark Boyett, Edward Lakatta, Victor A. Maltsev

11:00 am

INTERNATIONAL TRAVEL AWARDEE SK4 K + CHANNELS REGULATE SINOATRIAL PACEMAKER AND THEIR BLOCK- ADE AMELIORATE ARRHYTHMIAS IN CPVT2 PATIENT-DERIVED IPSC AND IN VIVO IN CASQ2 KNOCK-IN AND KNOCK-OUT MICE.  Shiraz Haron-Khun , David Weisbrod, Dor Yadin, Asher Peretz, Michael Eldar, Michael Arad, Bernard Attali 163-Plat 11:15 am ACTION POTENTIAL MORPHOLOGY MEASUREMENT OF CARDIAC CELL CHAMBER SPECIFIC CELL TYPES OF STEM CELL-DERIVED CARDIAC MYO- CYTES.  Aaron D. Kaplan, Glenna CL Bett, Randall L. Rasmusson 164-Plat 11:30 am FLUORESCENCE LOCAL FIELD OPTICAL MAPPING (FLOM) OF CA 2+ AL- TERNANSES TEMPERATURE DEPENDENCY IN INTACT PERFUSED MOUSE HEARTS.  Yuriana Aguilar-Sanchez , Moris A. Saravia, Jose Millet, Ariel L. Escobar 165-Plat 11:45 am SUDDEN INFANT DEATH AND MODULATION OF LATE SODIUM CURRENT BY HYPOXIA, INVESTIGATED IN INDUCED PLURIPOTENT STEM CELLS.  Stefan A. Mann , Jamie I. Vandenberg, Adam P. Hill 166-Plat 12:00 pm INCREASED SUSCEPTIBILITY OF SPONTANEOUSLY HYPERTENSIVE RATS TO VENTRICULAR TACHYARRHYTHMIAS DURING THE EARLY STAGES OF HYPERTENSION.  Christopher Y. Ko , Thao P. Nguyen, Ali A. Sovari, Arash Pezhouman, Shankar Iyer, Hong Cao, Aneesh Bapat, Nooshin Vahdani, Mostafa Ghanim, Michael C. Fishbein, James N. Weiss, Hrayr S. Karagueuzian 167-Plat 12:15 pm EXTRACELLULAR SODIUM DEPENDENCE OF THE CONDUCTION VELOCITY- CALCIUM RELATIONSHIP: EVIDENCE OF EPHAPTIC SELF-ATTENUATION.  Sharon George , Mohammad Bonakdar, Michael Zeitz, Rafael Davalos, James Smyth, Steven Poelzing 168-Plat 12:30 pm EVIDENCE FOR PHOSPHORYLATION-DEPENDENT MODULATION OF BK CHANNEL ACTIVITY IN VASCULAR SMOOTH MUSCLE (VSM) MYOCYTES AND RESISTANCE ARTERIES.  Barry D. Kyle, Ramesh C. Mishra, Andrew P. Braun Undergraduate Student Pizza “Breakfast” 11:30 am - 1:00 pm, Room 406AB The Education Committee hosts this “breakfast” for undergraduate stu- dents. This session provides a valuable networking and social opportunity to meet other students and Committee members, to discuss academic goals and questions, and to develop a biophysics career path. Space is limited to the first 100 registrants. Meeting attendees do not need to pre- register for this event. Colleges in the Community Day 11:30 am - 5:00 pm, Room 406AB This full day of activities for local college students and their instructors kicks off with an Undergraduate Student Pizza “Breakfast” where par- ticipants have an opportunity to socialize and network with their peers and members of the Biophysical Society’s Education Committee in a fun and relaxed environment. Next, students have a chance to win prizes during a scavenger hunt designed to promote learning and interaction with researchers. Undergraduates also have a unique opportunity to ask graduate students, postdocs, and leading biophysicists about training and career opportunities in biophysics and related fields during this interactive Q & A session. Come prepared to find out about the course of study that biophysicists undertake, what it means to be a biophysicist, and how biophysicists make important discoveries. Finally, students have access to an exclusive tour of the Exhibit Hall where they will view special demonstrations featuring cutting edge instrumentation producing break- throughs in structural biology and other areas.

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