Biophysical Society 60th Annual Meeting

183-Plat 4:30 pm STRUCTURAL BASIS OF NAV1.7 INHIBITION BY AN ISOFORM-SELECTIVE SMALL MOLECULE ANTAGONIST.  David H. Hackos , Shivani Ahuja, Susmith Mukund, Lunbin Deng, Kuldip Khakh, Elaine Chang, Clint Young, Sophia Lin, J.P. Johnson Jr., Daniel F. Ortwine, Brian S. Safina, Daniel P. Sutherlin, Charles J. Cohen, Christopher M. Koth, Jian Payandeh 184-Plat 4:45 pm MUTATION-SPECIFIC CARDIAC RISK ASSESSMENT IN LQT3.  Elsa Ronzier , Alessandra Matavel, Yitschak Biton, Niels Otani, Wojciech Zareba, Arthur J. Moss, Coeli Lopes 185-Plat 5:00 pm GENETICALLY ENCODING SINGLE-MOLECULE FLUOROPHORES INTO ION CHANNELS IN LIVING CELLS.  Lilia Leisle , Rahul Chadda, Jason D. Galpin, Janice L. Robertson, Christopher A. Ahern 186-Plat 5:15 pm GABAPENTINOIDS SUPPRESS EARLY AFTERDEPOLARIZATIONS BY UNCOU- PLING α 2 δ-1 SUBUNITS FROM CA V 1.2 CHANNELS: IMPLICATIONS FOR CA V CHANNEL GATING-MODIFIERS AS A NEW CLASS OF ANTIARRHYTHMICS.  Nicoletta Savalli , Marina Angelini, James N. Weiss, Riccardo Olcese 187-Plat 5:30 pm BIOPHYSICAL CHARACTERIZATION OF THE HONEYBEE’S DSC1 ORTHOLOG HIGHLIGHTS A NEW VOLTAGE DEPENDANT CALCIUM CHANNEL SUBFAM- ILY.  Pascal Gosselin-Badaroudine , Adrien Moreau, Louis Simard, Thierry Cens, Matthieu Rousset, Pierre Charnet, Mohamed Chahine 188-Plat 5:45 pm REGULATION OF MEMBRANE LOCALIZATION OF TYPE TWO VOLTAGE GATED CALCIUM CHANNELS. Mallory B. Scott , Paul J. Kammermeier Platform Membrane Structure 4:00 pm - 6:00 pm, Room 515A Co-Chairs Lisa Della Ripa, University of Illinois at Urbana-Champaign Tyler Reddy, University of Oxford, United Kingdom 189-Plat 4:00 pm THE COMPLEX, ASYMMETRIC, ESCHERICHIA COLI ENVELOPE STUDIED BY NEUTRON SCATTERING.  Luke A. Clifton, Stephen A. Holt, Nico Paracini, Arwel V. Hughes, Syma Khalid, Damien Jefferies, Jeremy H. Lakey 190-Plat 4:15 pm A COARSE GRAINED FORCE FIELD FOR PSEUDOMONAS AERUGINOSA PAO1 LIPOPOLYSACCHARIDE.  Brad J. Van Oosten , Thad A. Harroun 191-Plat 4:30 pm MOLECULAR INSIGHTS INTO THE LOW PERMEABILITY BARRIER OF GRAM- NEGATIVE PATHOGENS.  Cesar A. Lopez Bautista , S. Gnanakaran, Helen 4:45 pm COMPARTMENTAL VOLUME REGULATION OF E. COLI UNDER VARIOUS GROWTH CONDITIONS.  Jonas van den Berg , Bert Poolman 193-Plat 5:00 pm ATOMIC RESOLUTION STUDIES OF STEROL INTERACTIONS BY SOLID-STATE NMR SPECTROSCOPY.  Lisa A. Della Ripa , Alexander G. Cioffi, Samantha Phinney, Xiangyan Shi, Taras V. Pogorelov, Martin D. Burke, Chad M. Rienstra 194-Plat 5:15 pm INTERNATIONAL TRAVEL AWARDEE STRUCTURAL CHARACTERIZATION ON ASYMMETRIC LIPID VESICLES AT SUBNANOMETER RESOLUTION.  Barbara Geier , DrewMarquardt, Frederick Heberle, Milka Doktorova, John Katsaras, Georg Pabst Zgurskaya 192-Plat

171-Symp 5:00 pm MECHANISM AND FUNCTIONS OF PLATELET MECHANOSENSING. 

Renhao Li 172-Symp

F R I D A Y

S U N D A Y

5:30 pm CONFORMATIONAL PLASTICITY AND DRUGGABILITY OF MEMBRANE- BOUND K-RAS.  Alemayehu A. Gorfe Symposium Structure and Motion of Cilia and Flagella 4:00 pm - 6:00 pm, Petree Hall D Chair Jonathan Howard, Yale University 173-Symp 4:00 pm CRYO-ELECTRON TOMOGRAPHY PROVIDES A NEWWINDOW INTO CILI- ARY STRUCTURE AND FUNCTION.  Daniela Nicastro 174-Symp 4:30 pm STRUCTURAL GENETICS OF CILIA/FLAGELLA. Masahide Kikkawa 175-Symp 5:00 pm MOTOR COORDINATION UNDERLYING THE FLAGELLAR BEAT IN CHLAMYDOMONAS.  Jonathon Howard 176-Symp 5:30 pm SYNCHRONIZATION OF EUKARYOTIC FLAGELLA.  Raymond E. Goldstein Symposium DNA Nanostructures for Biophysics 4:00 pm - 6:00 pm, Room 502A Chair William Shih, Harvard University 177-Symp 4:00 pm DNA NANOSTRUCTURES AS BUILDING BLOCKS FOR MOLECULAR BIOPHYSICS AND FUTURE THERAPEUTICS. William Shih 178-Symp 4:30 pm CREATING PROGRAMMABLE DISORDER IN DNA ORIGAMI ARRAYS WITH COMBINATORIAL PATTERNS.  Lulu Qian , Grigory Tikhomirov, Philip Petersen 179-Symp 5:00 pm DNA ORIGAMI FOR NANOPORES: DESIGN, DEVELOPMENTS AND CHALLENGES.  Ulrich F. Keyser 180-Symp 5:30 pm NANOSCALE CONSTRUCTION AND IMAGING WITH DNA.  Peng Yin Platform Voltage-gated Channels (Na and Ca) 4:00 pm - 6:00 pm, Room 502B Co-Chairs RATIONAL DESIGN AND SYNTHESIS OF A NOVEL MEMBRANE BINDING NAV1.8 SELECTIVE INHIBITOR WITH IN VIVO ACTIVITY IN PAIN MODELS.  Christina I. Schroeder , Jennifer Deuis, Sonia Troeria Henriques, Zoltan Dekan, Marco Inserra, Mehdi Mobli, Irina Vetter 182-Plat 4:15 pm SODIUM CHANNEL/LIGAND COMPLEX STRUCTURES AS A GUIDE FOR RATIONAL DRUG DESIGN.  Altin Sula , Paul DeCaen, Claire Naylor, Geancarlo Zanatta, Claire Bagneris, David E. Clapham, David Pryde, B.A. Wallace Christopher Ahern, University of Iowa Coeli Lopes, University of Rochester 181-Plat 4:00 pm

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