Biophysical Society 60th Annual Meeting

Protein Structure and Conformation I (Boards B1 - B29) 221-Pos Board B1 STRUCTURAL AND MECHANISTIC INSIGHTS DERIVED FROM SATURATION MUTAGENESIS OF CCDB. Pankaj C. Jain , Siddharth Patel, Prasanth Kumar, Raghavan Varadarajan 222-Pos Board B2 STRUCTURAL AND FUNCTIONAL STUDY ON THE INTERACTION OF HU- MAN PLASMINOGEN AND PROTEIN H FROM HAEMOPHILUS INFLUENZAE TYPE F. Tamim Al-Jubair , Birendra Singh, Yu Ching Su, Susanna Törnroth Horsefield, Kristian Riesbeck 223-Pos Board B3 WHMD PROMOTES THE ASSEMBLY OF MYCOBACTERIUM SMEGMATIS FTSZ: A POSSIBLE ROLE OF WHMD IN BACTERIAL CELL DIVISION.  Dipanwita Bhattacharya , Ashutosh Kumar, Dulal Panda 224-Pos Board B4 ASSOCIATION MECHANISM OF LEISHMANIA MAJOR PEROXIDASE AND CYTOCHROME C REVEALED THROUGH BROWNIAN AND MOLECULAR DYNAMICS. Scott A. Hollingsworth , James B. Fields, Georges Chreifi, Matthias Heyden, Anton P. Arce, Hugo I. Magaña-Garcia, Douglas J. Tobias, Thomas L. Poulos 225-Pos Board B5 STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF CASK PDZ INTERACTION WITH PROTEIN AND LIPID BINDING PARTNERS. Young Joo Sun , Titus Hou, Xu Liu, Lokesh Gakhar, Ernesto Fuentes 226-Pos Board B6 NOVEL BIVALENT INTERACTION BETWEEN VASP-EVH1 AND ZYXIN IS CRITICAL FOR BINDING ORIENTATION. Lucila A. Acevedo , Alex I. Greenwood, Eric B. Gibbs, Scott Showalter, Linda Nicholson 227-Pos Board B7 CHARACTERIZING PROTEIN-PROTEIN NONSPECIFIC INTERACTIONS BY STATIC LIGHT SCATTERING. Di Wu , Huan-Xiang Zhou 228-Pos Board B8 STRUCTURAL STUDIES ON THE MITOCHONDRIAL FISSION PROTEIN FIS1 SUGGEST A MECHANISM OF TPR PROTEIN SELF-ASSOCIATION. Amber Bakkum , John Egner, Megan Cleland Harwig, Doug Bierer, R. Blake Hill 229-Pos Board B9 INTRINSICALLY-DISORDERED REGION OF HUMAN SMALL HEAT SHOCK PROTEIN HSPB1 AFFECTS STRUCTURE AND FUNCTION. Amanda F. Clouser , Ponni Rajagopal, Rachel E. Klevit 230-Pos Board B10 INTERPLAY BETWEEN IONIC STRENGTH, ASSOCIATION RATES AND ELEC- TROSTATIC INTERACTION IN THE C3D:CR2 COMPLEX. Rohith R. Mohan , Gary L. Huber, J. AndrewMcCammon, Dimitrios Morikis 231-Pos Board B11 CONFORMATIONAL CHANGES IN COMPLEMENT COMPONENT 3 UPON ACTIVATION OR THROMBOMODULIN BINDING. Daniel DeHelian, Gavin Palowitch, Nathan Fritzinger, Caroline Gambone, Thomas Holt, Shelby Marchese, Julia R. Koeppe 232-Pos Board B12 SYNERGY OF PUTATIVE BINDING MODES IN THE FACTOR H (CCP 19-20) AND C3D COMPLEX. Reed E S Harrison , Ronald D. Gorham, Dimitrios Morikis 233-Pos Board B13 THERMAL DENATURATION AND DOMAIN STABILITY OF NAMPT PRO- TEIN. Trivikram R. Molugu , Udeep Chawla, Radu C. Oita, Ting Wang, Michael F. Brown, Joe G. N. Garcia

234-Pos Board B14 STRUCTURE AND FUNCTION OF THE ASB-CONTAINING E3 LIGASES. Ryan

Lumpkin 235-Pos

F R I D A Y

S U N D A Y

Board B15 STRUCTURAL BASIS FOR CONFORMATIOANL SPACE OF LINEAR POLYUBIQ- UITIN BY CRYSTALLOGRAPHY AND SOLUTION SCATTERING. Trung Thanh Thach, Donghyuk Shin, Seungsu Han, Sangho Lee 236-Pos Board B16 A HYBRID METHODS APPROACH TO THE STRUCTURAL DETERMINATION OF PHOTOACTIVATION IN THE ORANGE CAROTENOID PROTEIN. Corie Ralston , Sayan Gupta 237-Pos Board B17 STRUCTURAL FRAMEWORK FOR PYRIDOXAL 5’-PHOSPHATE BINDING TO THE HUMAN GLUTAMATE-OXALOACETATE TRANSAMINASE VARI- ANTS. Jesi Lee, Peter Ngoi, Trevor Gokey, Xiao Chang, Ten-Yang Yen, Yanping Tan, Hongyun Tong, Zheng-Hui He, Anton Guliaev 238-Pos Board B18 CONFORMATIONAL DIFFERENCES BETWEEN ERK2 AND JNK3α1.  Ji Young Park , Ka Young Chung 239-Pos Board B19 COMPARISON OF THE CONFORMATIONAL DYNAMICS BETWEEN DIFFER- ENT ACTIVE STATES OF β-ARRESTIN1 ANALYZED BY HYDROGEN/DEUTERI- UM EXCHANGE MASS SPECTROMETRY. Hee Ryung Kim , Ka Young Chung 240-Pos Board B20 STRUCTURE-DYNAMIC DETERMINANTS GOVERNING A MODE OF REGU- LATORY RESPONSE AND PROPAGATION OF ALLOSTERIC SIGNAL IN SPLICE VARIANTS OF NA + /CA 2+ EXCHANGE (NCX) PROTEINS. Su Youn Lee , Ka Young Chung, Daniel Khananshvili, Moshe Giladi 241-Pos Board B21 THE E.COLI SEC PATHWAY UNDER A SINGLE-MOLECULE LOUPE. Niels Vandenberk, Spiridoula (Lily) Karamanou, Anastassios (Tassos) Economou, Johan Hofkens, Jelle Hendrix 242-Pos Board B22 SYMMETRY-CONSTRAINED NORMAL MODE ANALYSIS OF THE BACTERIAL FLAGELLAR MOTOR. Moon Ki Choi , Soojin Jo, Moon Ki Kim 243-Pos Board B23 RESOLVING CONFORMATIONAL SWITCHES IN THE PROTEASE FTSH USING SINGLE-MOLECULE FRET. Martine Ruer , Philip Gröger, Krainer Georg, Michael Schlierf 244-Pos Board B24 STRUCTURAL CHANGES IN THE SNARE PROTEIN SNAP ‐ 25 BY PH AND IONIC STRENGTH. Kyle S. Clawson , David Hallan, Timothy T. Harris, Katrina J. Welker, Kara L. Woodbury, Dixon J. Woodbury 245-Pos Board B25 MECHANISM OF COORDINATION OF THE BACTERIOPHAGE T4 DNA PACKAGING MOTOR ANALYZED BY REAL-TIME SINGLE MOLECULE FLUO- RESCENCE ASSAY. Li Dai , Digvijay Singh, Reza Vafabakhsh, Marthandan Mahalingam, Vishal Kottadiel, Yann Chemla, Taekjip Ha, Venigalla B. Rao 246-Pos Board B26 LID CONFORMATIONAL DYNAMICS AND SUBSTRATE SPECIFICITY OF THE PILI CONSTRUCTING SORTASE C ENZYMES. Emmanuel Naziga , Jeff Wereszczynski 247-Pos Board B27 A NOVEL SIGNAL TRANSDUCTION MECHANISM IN LOV DOMAIN PRO- TEINS. Estella F. Yee , Anand T. Vaidya, Peter P. Borbat, Jack H. Freed, Brian R. Crane

23