Biophysical Society 60th Annual Meeting

496-Pos Board B276 INTERNATIONAL TRAVEL AWARDEE MECHANICAL REGULATION OF NUCLEAR SHAPE AND VOLUME. Dong- Hwee Kim , Bo Li, Fangwei Si, Jude Phillip, Denis Wirtz, Sean X. Sun 497-Pos Board B277 MECHANOSENSING DEFECTS IN NUCLEAR ENVELOPE RELATED DISOR- DERS. Christine Technau, Martina Fischer, Kamel Mamchaoui, Anne Bigot, Thevy Lok, Claude Verdier, Alain Duperray, Thomas Voit, Susana Quijano- Roy, Gisèle Bonne, Catherine Coirault 498-Pos Board B278 CYCLIC STRAIN OF PRECISION CUT LUNG SLICES (PCLS) INDUCES PRO- INFLAMMATORY AND PRO-PROLIFERATIVE SIGNALLING. David Salman , Charlotte Dean, Mark J. D Griffiths Excitation-Contraction Coupling I (Boards B279 - B301) 499-Pos Board B279 RYANODINE RECEPTOR SENSITIVITY GOVERNS THE STABILITY AND SYNCHRONY OF LOCAL CALCIUM RELEASE DURING CARDIAC EXCITATION- CONTRACTION COUPLING. Andrew P. Wescott , M. Saleet Jafri, W. Jonathan Lederer, George S. B. Williams 500-Pos Board B280 DANTROLENE INHIBITION OF SKELETAL MUSCLE RYR IN THE PRESENCE OF CAM. Ye W. Oo , M.S Imtiaz, D.F. vanHelden, D.R Laver 501-Pos Board B281 NOVEL COMPOUNDS INHIBIT CALMODULIN DEFICIENT RYR2 ACTIVITY AND ARRHYTHMIAS IN A CPVT MOUSE MODEL. Robert C. Klipp , Na Li, Qiongling Wang, Martha Sibrian-Vazquez, Robert M. Strongin, Xander H.T. Wehrens, Jonathan J. Abramson 502-Pos Board B282 INTERNATIONAL TRAVEL AWARDEE S4-S5 LINKER REGULATES RYR2 CHANNEL GATING THROUGH MULTIPLE INTERACTIONS. Takashi Murayama , Nagomi Kurebayashi, Haruo Ogawa, Junji Suzuki, Kazunori Kanemaru, Masamitsu Iino, Takashi Sakurai 503-Pos Board B283 SPONTANEOUS AND VOLTAGE-ACTIVATED ELEMENTARY CALCIUM RELEASE EVENTS IN INTACT SKELETAL MUSCLE FIBERS EXPRESSING THE EMBRYONIC CAV1.1 SPLICE VARIANT. Beatrix Dienes , János Vincze, Péter Szentesi, Nasreen Sultana, Berhnard E. Flucher, László Csernoch 504-Pos Board B284 CHARACTERIZATION OF THE STAC3-CAV1.1 INTERACTION IN SKELETAL MUSCLE EXCITATION-CONTRACTION COUPLING. Marta Campiglio , Bernhard E. Flucher 505-Pos Board B285 THE TRANSMEMBRANE DOMAIN IS SUFFICIENT TO DIRECT JUNC- TOPHILIN-1 LOCALIZATION AT THE JUNCTIONAL SR. Daniela Rossi , Angela Maria Scarcella, Stefania Lorenzini, Vincenzo Sorrentino 506-Pos Board B286 CELLULAR PATHOPHYSIOLOGY OF “MHH”, A LARGE GROUP OF PATIENTS WITH EQUIVOCAL DIAGNOSIS OF MALIGNANT HYPERTHERMIA. Lourdes Figueroa , Carlo Manno, Natalia Kraeva, Sheila Toro, Eduardo Rios, Sheila Riazi 507-Pos Board B287 THE MALIGNANT HYPERTHERMIA RYR1Y522S MUTATION AFFECTS CAL- CIUM HOMEOSTASIS IN ARTERIAL SMOOTH MUSCLE CELLS. Ruben Lopez, Susan N. Treves, Francesco Zorzato 508-Pos Board B288 INACTIVATION OF CAV1.1 CHANNELS IN ADULT SKELETAL MUSCLE: EF-

FECTS OF A C-TERMINAL PRE-IQ MUTATION. Erick O. Hernández-Ochoa , Brian R. Cannon, Camilo Vanegas, David J. Weber, Martin F. Schneider 509-Pos Board B289 STIM1-DEPENDENT CA2+ SIGNALING IN CARDIAC MYOCYTES. Cory Parks, Ryan Sullivan, Salvatore Mancarella 510-Pos Board B290 MODELING THE ROLE OF NCX IN THE REGULATION OF CARDIOMYO- CYTE MICRODOMAIN CA 2+ DYNAMICS. Lulu Chu , Joseph L. Greenstein, Raimond L. Winslow 511-Pos Board B291 TRANSMURAL DIFFERENCES IN PRELOAD-DEPENDENCY OF CA 2+ TRAN- SIENTS IN ISOLATED CARDIOMYOCYTES. Anastasia Khokhlova , Gentaro Iribe, Olga Solovyova 512-Pos Board B292 THE TRPV4 ION CHANNEL ALTERS INTRACELLULAR CALCIUM TRANSIENTS IN CARDIOMYOCYTES OF AGED MICE.  John L. Jones , Michelle D. Lambert, Justin T. Whitfield, Timothy L. Domeier 513-Pos Board B293 THE CONCENTRATIONS OF TOTAL CALCIUM IN FAST-TWITCH AND HEART MUSCLES FROMMICE IN AN AGITATED AND ACTIVE STATE IS ALMOST 2-FOLD GREATER THAN THOSE FROM RESTING MICE. Abby F. McDonell, Paul C. Pape 514-Pos Board B294 CA2+ TIDES IN CARDIOMYOCYTES UNDER MECHANICAL LOADING. Zhong Jian , Leighton T Izu, Yi-Je Chen, Brittani Wood, Julie Bossuyt, Kit S Lam, Ye Board B295 DYSSYNCHRONOUS CA REMOVAL IN ATRIAL CARDIAC MYOCYTES. Felix Hohendanner , Frank Heinzel, Lothar Blatter 516-Pos Board B296 INTEPLAY OF TRIGGER CA 2+ WAVES AND CA 2+ TRANSIENT ALTERNANS IN ATRIAL MYOCYTES. Gary Aistrup , Yohannes Shiferaw, Rishi Arora, Georg Gussak, Soren Grubb, WilliamMarszalec, J. AndrewWasserstrom 517-Pos Board B297 ACTIVATION OF REVERSE NA/CA EXCHANGER BY SKELETAL NA CHANNEL ISOFORM INCREASES EXCITATION-CONTRACTION COUPLING EFFICIENCY IN RABBIT CARDIOMYOCYTES. Natalia S. Torres , John HB Bridge 518-Pos Board B298 USING ACTION POTENTIAL CLAMP DATA TO DETERMINE THE CALCIUM FLUXES AND CONTRIBUTIONS IN EXCITATION-CONTRACTION COUPLING IN VIVO IN CARDIOMYOCYTES. Martin Laasmaa , Marko Vendelin, Rikke Board B299 CHARACTERIZATION OF TWO HUMAN SKELETAL CALSEQUESTRIN MU- TANTS IMPLICATED IN MALIGNANT HYPERTHERMIA AND VACULOLAR AGGREAGTES MYOPATHY. Eduardo Rios , Kevin M. Lewis, Leslie A. Ronish, ChulHee Kang 520-Pos Board B300 IMAGING STUDIES OF CALSEQUESTRIN STRUCTURE IN SKELETAL MUSCLE. EFFECTS OF CALCIUM RELEASE. Eduardo Rios , Carlo Manno, Lourdes Figueroa, Clara Franzini-Armstrong 521-Pos Board B301 MECHANICAL ANALYSIS OF SINGLE MYOCYTE CONTRACTION IN A 3D VISCOELASTIC GEL.  John A. Shaw , Alan Wineman, Rafael Shimkunas, Leighton Izu, Ye Chen-Izu Chen-Izu 515-Pos Birkedal 519-Pos

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