Biophysical Society 60th Annual Meeting

626-Pos Board B406 STRUCTURE AND FUNCTION OF THE LEVOSIMENDAN ANALOG I9 CO- VALENTLY BOUND TO CARDIAC TROPONIN C. Sandra Elizabeth Pineda- Sanabria , Ian M. Robertson, Yin-Biao Sun, Malcolm Irving, Brian D. Sykes 627-Pos Board B407 PRIMARY EFFECTS OF HCMMUTATIONS IN HUMANS AND CATS. Andrew E. Messer , Mary Papadaki, Petr G. Vikhorev, Yousef Sebzali, Mohammed El-Mezgueldi, Alex Daley, David J. Connolly, Steven B. Marston 628-Pos Board B408 THERMODYNAMICS OF CALCIUM BINDING TO ZEBRAFISH TROPONIN C (TNC) VISUALIZED THROUGH ISOTHERMAL TITRATION CALORIMETRY (ITC) AND MOLECULAR DYNAMICS (MD). Kaveh Rayani , Charles M. Stevens, Bo Liang, Christine E. Genge, Glen F. Tibbits 629-Pos Board B409 A8V MUTATION OF CARDIAC TROPONIN C ENHANCES TROPONIN I BIND- ING.  Javier E. Hasbun , Henry G. Zot, Clara A. Michel, Maicon Landim- Vieira, Jose R. Pinto 630-Pos Board B410 THE REGULATION OF ATP-BINDING, PI RELEASE AND ADP DISSOCIATION FROMMYOSIN II IN NATIVE CARDIAC MYOFIBRILS BY THE N-TERMINAL EXTENSION OF CARDIAC TROPONIN T. Laura Gunther , Han-Zhong Feng, Jian-Ping Jin, Takeshi Sakamoto 631-Pos Board B411 A NOVEL TRYPTOPHAN ANALOG DESIGNED FOR STUDYING CALCIUM IN- DUCED CONFORMATIONAL CHANGE OF TROPONIN C. Alison Y. Li , Kaveh Rayani, Danielle Wilson, Neil Branda, Glen Tibbits 632-Pos Board B412 CARDIOMYOPATHY LINKED MUTATIONS IN ALPHA TROPOMYOSIN INFLUENCE BLOCKED STATE STABILITY BUT NOT MYOSIN STRONG BIND- ING. Gerrie P. Farman, Michael Rynkiewicz, Marek Orzechowski, William Lehman, Jeffrey Moore 633-Pos Board B413 NOVEL POTENTIAL TREATMENT OF FAMILIAL HYPERTROPHIC CARDIOMY- OPATHY WITH ANALOGUES OF THE GREEN TEA POLYPHENOL EPIGALLO- CATECHIN-3-GALLATE. Paul J. Robinson , Suketu Patel, Xing Liu, Yin-Hua Zhang, Anuj Khandelwal, Brian Blagg, Barbara Casadei, Hugh Watkins, Charles Redwood  Actin Structure, Dynamics, and Associated Proteins (Boards B414 - B429) 634-Pos Board B414 SPECIFIC CATION BINDING STIFFENS ACTIN FILAMENTS BY ADHERING D-LOOPS TO ADJACENT MONOMERS. Glen M. Hocky , Joseph L. Baker, Michael J. Bradley, Anton V. Sinitskiy, Enrique M. De La Cruz, Gregory A. Voth 635-Pos Board B415 C0 AND C1 N-TERMINAL IG-DOMAINS OF MYOSIN BINDING PROTEIN-C EXERT DIFFERENT EFFECTS ON THIN FILAMENT ACTIVATION. Samantha P. Harris, Betty Belknap, Howard D. White, Vitold E. Galkin 636-Pos Board B416 CID TRAVEL AWARDEE MOLECULAR MECHANISM OF α-ACTININ BINDING TO F-ACTIN: EFFECT OF K255E MUTATION. Hengameh Shams , Kiavash Garakani, Javad Golji, Mohammad R. K. Mofrad 637-Pos Board B417 3D MODEL OF FISSION YEAST CONTRACTILE RING ASSEMBLY: EFFECTS OF CYTOKINETIC NODE INTERACTION WITH THE CELL MEMBRANE AND MYOSIN MOTORS. Tamara C. Bidone , Dimitrios Vavylonis

638-Pos Board B418 SIMULATION OF THE EFFECT OF CONFINEMENT IN ACTIN RING FORMA- TION. Maral Adeli Koudehi , Haosu Tang, Dimitrios Vavylonis 639-Pos Board B419 ROLE OF CROSS-LINKERS IN YEAST BRANCHED ACTIN NETWORKS: LINK- ING BIOCHEMISTRY AND MECHANICS.  Jessica Planade , Audrey Guillotin, Alphée Michelot, Olivia du Roure, Julien Heuvingh 640-Pos Board B420 SELF-ORGANIZATION OF ACTOMYOSIN NETWORKS ATTACHED TO ARTIFI- CIAL MEMBRANES. Markus Schön , Corinna Kramer, Helen Noeding, Ingo Mey, Andreas Janshoff, Claudia Steinem 641-Pos Board B421 DIFFERENCES IN THE SPATIAL DISTRIBUTION OF ACTIN IN THE LEFT AND RIGHT VENTRICLES OF HEALTHY HUMAN HEARTS.  Janhavi Nagwekar , Divya Duggal, Ryan Rich, Sangram Raut, Zygmunt Gryczynski, Julian Board B422 NOVEL MECHANISMS OF FRNK INHIBITION OF FAK IN VASCULAR SMOOTH MUSCLE CELLS. Taylor J. Zak , Allen Samarel, Seth Robia 643-Pos Board B423 ACTIN POLYMERIZATION AND BUNDLING: EXPLORING THEIR TEMPERA- TURE AND PRESSURE LIMITS. Mimi Gao , Melanie Berghaus, Julian von der Ecken, Stefan Raunser, Roland Winter 644-Pos Board B424 REAL-TIME PROBING OF THE EGFR-MEDIATED CELL SIGNALING USING MICRO-SCALE SURFACE ENHANCED RAMAN SPECTROSCOPY SYSTEM. Yi- Jie Lu 645-Pos Board B425 HOW SYNERGY OF ACTIN ASSEMBLY-DISASSEMBLY AND MYOSIN MO- TORS DRIVES CELL SHAPE CHANGES. Valentina Caorsi , Wu Sangsong, Joël Lemiere, Clément Campillo, Timo Betz, Julie Plastino, Cécile Sykes 646-Pos Board B426 LOCAL FORCES IN ACTIN NETWORKS WITH GRADIENTS. Erin Rericha , Austin N. Oleskie 647-Pos Board B427 THE ACTIN F352S NEMALINE MYOPATHY MUTATION DISRUPTS INDIRECT FLIGHT MUSCLE STRUCTURE AND FUNCTION IN DROSOPHILA. Manuela Lavorato , William Schmidt, Meera C. Viswanathan, Julien Ochala, Clara Franzini-Armstrong, Anthony Cammarato 648-Pos Board B428 SPECTROSCOPIC AND COMPUTATIONAL ANALYSIS OF DYSTROPHIN REGULATION OF ACTIN DYNAMICS. Michael E. Fealey , Benjamin Horn, Alessandro Cembran, Anne Hinderliter, David D. Thomas 649-Pos Board B429 BETA-ADRENERGIC AGONIST REDUCES THE DEFORMABILITY OF HUMAN BREAST CANCER CELLS. Tae-Hyung Kim , Navjot Gill, Erica Sloan, Amy Rowat Microtubules, Structure, Dynamics, and Associated Proteins (Boards B430 - B445) 650-Pos Board B430 EFFECTS OF SPERMINE ON MICROTUBULE STRUCTURES. Chola K. Regmi , Shengfeng Cheng 651-Pos Board B431 DERIVING MECHANICAL PROPERTIES OF MICROTUBULES FROMMO- LECULAR SIMULATIONS. Soheil Fatehiboroujeni , Sachin Goyal Borejdo 642-Pos

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