SPADA Docs

155 Figure 3 (Courtesy: Kristin Jones Maia, DBPAO internal brief). Examples of the timeline for 156 obtaining Ebola reference materials from Africa. A delay in obtaining pathogen reference 157 materials may hamper the discovery of signature erosion and the follow-on development of new 158 or ‘old and improved’ detection assays, thereby delaying an effective assay from reaching the 159 field in a timely manner. ID- Identity, DRC- Democratic Republic of Congo, CRP- Critical 160 Reagents Program, CBEP- Cooperative Biological Engagement Program, USAMRIID- United 161 States Army Medical Research Institute of Infectious Diseases, DoD- Department of Defense, 162 NEJM- New England Journal of Medicine, EBOV- Zaire Ebola Virus. 165 biology approaches to reduce the need for live/inactivated pathogen samples. While in silico 166 assay design approaches cannot circumvent the need for experimental testing against actual 167 pathogens in relevant biological samples, in silico methods can be used to direct the 168 163 164 Hence, there is a heightened impetus for developing robust in silico methods and synthetic

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