170135_inorganicventures_flipping

Summary

1. Know the limitations of ICP-MS - What affects sensitivity? (abundance, ionization energy, mass) - Lower mass, more concerns (Ar, Cl, matrix) - Few masses are free of potential interferences 2. Internal standards - Critical for ‘tough’ samples - Significant IS corrections can introduce significant error - Can suffer interferences (selection critical) 3. Interferences - Isobaric (easy) vs. polyatomic (tough) - Function of matrix (polyatomic) – both sample and reagents - Instrument specific

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