APBI 2016

Dose to the heart

Darby et al., NEJM, 2013. Rates of major coronary events increased linearly with the mean dose to the heart by 7.4% per gray with no apparent threshold.

Lee at al. Am J Cardiol, 2013. Patients with left-sided breast cancer treated with radiotherapy have a higher risk of severe stenosis involving the mid and distal left anterior descending arteries and the distal diagonal branches.

LAD artery dose ≈ maximum dose to small volume