Upper GI 2016

State of art of radiation therapy in Esophageal Cancer ü Preoperative Chemoradiation à Planned Esophagectomy

• Walsh et al – 1996 (Trimodality) • Urba et al – 2001 (Trimodality) • Burmeister et al – 2005 (Trimodality) • Tepper et al – 2008 (Trimodality) • CROSS - 2015 (Trimodality) • FFCD 9901 - 2014 (Trimodality) • POET - 2009 (Trimodality)

Phase III Trial Chir ± Preop RTCT Phase III Trial Chir ± Preop RTCT Phase III Trial Chir ± Preop RTCT Phase III Trial Chir ± Preop RTCT Phase III Trial Chir + Preop CT ± RT Phase III Trial Chir ± Preop RTCT Phase III Trial Chir ± Preop RTCT

ü Definitive Chemoradiation à Salvage Esophagectomy

• RTOG 85-01 - 1999 • INT 0123 - 2002

Phase III Trial RT vs RTCT

Phase III Trial RTCT (50Gy) vs RTCT (65Gy)

ü Chemoradiation à or Selective Esophagectomy

Phase II Trial RTCT ± Selective Chir

• FFCD 9102 - 2015 • ESSEN Trial - 2005

Phase III Trial RTCT in > PR RTCT vs Selective Chir