Upper GI 2016

Toxicities associated with monthly 5FU/DDP

severe GI toxicity

severe hematol tox

life- threatening

Study

Arms

RT

N histol

64Gy (2Gy/f)

RT alone

60

18%

3%

3%

20%SCC 80%ADC

Herscovic 1992

RCT (monthly DDP/5FU)

41% (incl 33% stomatitis)

50Gy (2Gy/f)

61

48%

20%

Surg alone

-

58

-

-

-

Walsh

preopRCT 40Gy

100%ADC

1995

(monthly DDP/5FU)

(2.6Gy/f )

55

5%

4%

5%

47% (incl 27% stomatitis)

monthly DDP/5FU

VanCutsem 2006

-

224 100%ADC

57%

12%