C H A P T E R 3 5
Hypothalamic and pituitary agents
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C H E C K Y O U R U N D E R S T A N D I N G
Answers to the questions in this chapter can be found in
Appendix A at the back of this book.
MULTIPLE CHOICE
Select the best answer to the following.
1.
Hypothalamic hormones are normally present in
very small amounts. When used therapeutically,
their main indication is:
a.
diagnosis of endocrine disorders and treatment of
specific cancers.
b.
treatment of multiple endocrine disorders.
c.
treatment of CNS-related abnormalities.
d.
treatment of autoimmune-related problems.
2.
Somatropin (
Genotropin
and others) is a genetically
engineered growth hormone that is used:
a.
to diagnose hypothalamic failure.
b.
to treat precocious puberty.
c.
in the treatment of children with growth failure.
d.
to stimulate pituitary response.
3.
Growth hormone deficiencies:
a.
occur only in children.
b.
always result in dwarfism.
c.
are treated only in children because GH is
usually produced only until puberty.
d.
can occur in adults as well as children.
4.
People who are receiving growth hormone
replacement therapy must be monitored very closely.
Routine follow-up examinations would include:
a.
a bowel program to deal with constipation.
b.
tests for thyroid function and glucose tolerance.
c.
a kilojoule check to control weight gain.
d.
tests of adrenal hormone levels.
5.
Acromegaly and gigantism are both conditions
related to excessive secretion of:
a.
thyroid hormone.
b.
melanin-stimulating hormone.
c.
growth hormone.
d.
oxytocin.
6.
Diabetes insipidus is a relatively rare disease
characterised by:
a.
excessive secretion of ADH.
b.
renal damage.
c.
the production of large amounts of dilute urine
containing no glucose.
d.
insufficient pancreatic activity.
7.
Treatment with ADH preparations is associated with
adverse effects, including:
a.
constipation and paralytic ileus.
b.
cholecystitis and bile obstruction.
c.
nocturia and bed wetting.
d.
“hangover” symptoms, including headache,
sweating and tremors.
8.
A person who is receiving an ADH preparation
for diabetes insipidus may need instruction in
administering the drug:
a.
orally or intramuscularly.
b.
orally or intranasally.
c.
rectally or orally.
d.
intranasally or by dermal patch.
MULTIPLE RESPONSE
Select all that apply.
1.
Octreotide (
Sandostatin
) would be the drug of
choice in the treatment of acromegaly in a person
with which of the following conditions?
a.
diabetes
b.
gallbladder disease
c.
adrenal insufficiency
d.
hypothalamic lesions
e.
intolerance to other therapies
f.
acromegaly in a person older than the age of
18 years
2.
A father brought his 15-year-old son to the
endocrine clinic because the boy was only
152 centimetres tall. He wanted his son to receive
growth hormone therapy because short stature
would be a detriment to his success as an adult.
The boy would be considered for this therapy under
which of the following circumstances?
a.
If he were against the use of cadaver parts.
b.
If his epiphyses were closed.
c.
If his GH levels were very low.
d.
If he were also diabetic.
e.
If he had chronic renal failure.
f.
If he had hypothyroidism.
