C H A P T E R 4 3
Drugs affecting blood pressure
665
TABLE 43.2
DRUGS IN FOCUS Antihypertensive agents (continued)
Drug name
Dosage/route
Usual indications
Angiotensin-converting-enzyme (ACE) inhibitors (continued)
quinapril (Accupril, Acquin,
Qpril)
20–80 mg/day PO, based on response for
hypertension; 10–20 mg PO b.d. for HF;
reduce dose in people with renal impairment
and in geriatric people
Treatment of hypertension; adjunctive
treatment of HF; for use in adults
ramipril (Prilace, Ramace)
2.5–20 mg/day PO for hypertension; 5 mg PO
b.d. for HF; reduce dose in geriatric people
and people with renal impairment
Treatment of hypertension; adjunctive
treatment of HF; for use in adults
trandolapril (Dolapril,
Gopten)
1–2 mg PO q.i.d. for hypertension; 4 mg/day
PO, titrate slowly to that level for HF; reduce
dose in people with renal or hepatic
impairment
Treatment of hypertension, HF, and after
MI; for use in adults
Angiotensin II-receptor blockers
candesartan (Atacand)
16–32 mg/day PO
Used alone or as part of combination
therapy for treatment of hypertension in
adults
eprosartan (Teveten)
400–800 mg/day PO
Used alone or as part of combination
therapy for treatment of hypertension in
adults
irbesartan (Abisart,
Avapro)
150–300 mg/day PO
Used alone or as part of combination
therapy for treatment of tension in
adults; slowing progression of diabetic
nephropathy in people with hypertension
and type 2 diabetes
losartan (Cozaar,
Cozavan)
25–100 mg/day PO
Used alone or as part of combination
therapy for treatment of hypertension in
adults; slowing progression of diabetic
nephropathy with elevated serum
creatinine and proteinuria in people with
hypertension and type 2 diabetes
olmesartan (Olmetec)
20–40 mg/day PO
Used alone or as part of combination
therapy to treat hypertension in adults
(newest angiotensin II–receptor blocker)
telmisartan (Micardis)
40–80 mg/day PO
Used alone or as part of combination
therapy for treatment of hypertension in
adults
valsartan (Diovan)
80–320 mg/day PO based on response
Used alone or as part of combination
therapy for treatment of hypertension
in adults; treatment of heart failure
in people who are intolerant to ACE
inhibitors
Calcium channel blockers
amlodipine (Norvasc)
2.5–10 mg/day PO; reduce dose in people with
hepatic impairment and in older adults
Used alone or in combination with other
agents for treatment of hypertension and
angina in adults
diltiazem (Cardizem,
Dilzem)
60–120 mg PO b.d.
Extended-release preparation used to treat
hypertension in adults; other preparations
are used for angina
felodipine (Fendex ER,
Plendil ER)
10–15 mg/day PO; do not exceed 10 mg/day
in geriatric people or in people with hepatic
impairment
Used alone or in combination with other
agents for treatment of hypertension in
adults
isradipine (DynaCirc)
2.5–10 mg PO b.d.; 5–10 mg/day PO—
controlled release
Used alone or in combination with thiazide
diuretics for treatment of hypertension in
adults
Continued on following page
